Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR1E | P28566 | 1/20 | 0.37 |
| ▸ | HTR1F | P30939 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HTR5A | P47898 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9624504 | 0.90 | HTR2A (0.43) | DRD2HTR2AMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL9624748 | 0.88 | BCHE (0.44) | DRD2HTR2AMAPTNPSR1HTR3E | |
| SCHEMBL9624887 | 0.86 | HTR6 (0.45) | HTR2AMAPTSMN1; SMN2NPSR1HTR6 | |
| SCHEMBL9624496 | 0.85 | KMT2A (0.46) | DRD2HTR2AMAPTHTR3EHTR3B | |
| SCHEMBL9625146 | 0.82 | SLC6A4 (0.46) | DRD2HTR2AHTR3EHTR3BHTR1A | |
| SCHEMBL9625049 | 0.81 | HTR1A (0.49) | HTR2AMAPTSMN1; SMN2HTR3EHTR3B | |
| SCHEMBL9625131 | 0.80 | SIGMAR1 (0.35) | — | |
| SCHEMBL9623773 | 0.80 | BCHE (0.46) | DRD2HTR2AMAPTSMN1; SMN2HTR1A | |
| SCHEMBL9625186 | 0.79 | SMPD1 (0.34) | MAPT | |
| SCHEMBL9624939 | 0.78 | HTR1D (0.54) | MAPTSMN1; SMN2HTR1DHTR6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| EP-0269968-A2 | Heteroaromatic amine derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-06-08 | — | — | EP | disclosed |