Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR1E | P28566 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9624496 | 0.89 | KMT2A (0.46) | HTR1AHTR2AHTR2CHTR2BMAPT | |
| SCHEMBL9625146 | 0.89 | SLC6A4 (0.46) | HTR1AHTR2AHTR2CHTR2BSLC6A3 | |
| SCHEMBL9624802 | 0.88 | DRD2 (0.40) | HTR1AHTR2AHTR2CHTR2BMAPT | |
| SCHEMBL9623773 | 0.88 | BCHE (0.46) | BCHEHTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL9625049 | 0.87 | HTR1A (0.49) | HTR1AHTR2AHTR2CHTR2BMAPT | |
| SCHEMBL9624939 | 0.86 | HTR1D (0.54) | MAPTMEN1KMT2AHTR6HTR1D | |
| SCHEMBL9624830 | 0.85 | CDK4 (0.46) | BCHEHTR1AHTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL9625229 | 0.85 | CDK4 (0.46) | BCHEHTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL10892578 | 0.84 | MAPT (0.48) | BCHEHTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL9625131 | 0.83 | SIGMAR1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| US-4912115-A | Cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1990-03-27 | — | — | US | disclosed |