Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9624476 | 0.87 | MAPT (0.38) | SMPD1DRD2DRD3SIGMAR1MAPT | |
| SCHEMBL9623732 | 0.87 | MAPT (0.44) | SMPD1MAPTHCN4CYP3A4ALOX15 | |
| SCHEMBL9624538 | 0.86 | BCHE (0.37) | SMPD1DRD2DRD3SIGMAR1 | |
| SCHEMBL9623887 | 0.83 | HDAC6 (0.34) | SMPD1DRD2DRD3MAPTHCN4 | |
| SCHEMBL10400846 | 0.82 | MAPT (0.40) | SMPD1MAPTHCN4CYP3A4ALOX15 | |
| SCHEMBL9624963 | 0.82 | HDAC6 (0.34) | SMPD1DRD2DRD3SIGMAR1MAPT | |
| SCHEMBL9625068 | 0.81 | HDAC6 (0.35) | DRD2DRD3SIGMAR1MAPTHCN4 | |
| SCHEMBL9625079 | 0.81 | LMNA (0.39) | SMPD1 | |
| SCHEMBL9624544 | 0.81 | SIGMAR1 (0.43) | DRD2DRD3SIGMAR1CYP3A4LTA4H | |
| SCHEMBL9624961 | 0.79 | LMNA (0.39) | DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| US-4912115-A | Cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1990-03-27 | — | — | US | disclosed |