Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9625440 | 0.87 | MEN1 (0.56) | HTR2AHTR1AHRH1GRIN2BSIGMAR1 | |
| SCHEMBL9457489 | 0.87 | OPRM1 (0.42) | OPRM1HTR2AHTR1ADRD4HRH1 | |
| SCHEMBL9457492 | 0.87 | OPRM1 (0.42) | OPRM1HTR2AHTR1ADRD4HRH1 | |
| SCHEMBL9625460 | 0.80 | SMN1; SMN2 (0.39) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL7357273 | 0.79 | OPRM1 (0.55) | OPRM1HTR2AHTR1ADRD4HRH1 | |
| SCHEMBL9624898 | 0.78 | MAPT (0.44) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL5697159 | 0.78 | NPC1 (0.58) | OPRM1HTR2AHTR1ADRD4HRH1 | |
| SCHEMBL9625529 | 0.78 | GAA (0.55) | CYP1A2CYP3A4SMN1; SMN2NPC1RAB9A | |
| SCHEMBL9626334 | 0.77 | POLB (0.34) | L3MBTL1SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL9625616 | 0.76 | SMN1; SMN2 (0.33) | SMN1; SMN2RAB9AMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0308283-B1 | 1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXALDEHYDE OXIME DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1992-01-22 | — | — | EP | disclosed |
| EP-0308283-A1 | 1,2,5,6-Tetrahydropyridine-3-carboxaldehyde oxime derivatives, process for their preparation, their use as pharmaceutical compounds and compositions containing them | ROUSSEL-UCLAF (FR) | 1989-03-22 | — | — | EP | disclosed |