Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.43 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | IDE | P14735 | 1/20 | 0.35 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.35 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.35 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12081760 | 1.00 | CYP2C9 (0.47) | CYP2C9NPSR1GLO1ALDH1A1CYP2D6 | |
| SCHEMBL962611 | 1.00 | CYP2C9 (0.47) | CYP2C9NPSR1GLO1ALDH1A1CYP2D6 | |
| SCHEMBL3589914 | 0.88 | CYP2C9 (0.46) | CYP2C9NPSR1GLO1ALDH1A1CYP2D6 | |
| SCHEMBL13100602 | 0.87 | NPSR1 (0.41) | CYP2C9NPSR1GLO1ALDH1A1CYP2D6 | |
| SCHEMBL18936293 | 0.85 | NPSR1 (0.42) | CYP2C9NPSR1GLO1ALDH1A1CYP2D6 | |
| SCHEMBL18936291 | 0.85 | NPSR1 (0.42) | CYP2C9NPSR1GLO1ALDH1A1CYP2D6 | |
| SCHEMBL1587531 | 0.84 | CYP2C9 (0.49) | CYP2C9NPSR1GLO1ALDH1A1CYP2D6 | |
| SCHEMBL5901707 | 0.84 | CYP2C9 (0.49) | CYP2C9NPSR1GLO1ALDH1A1CYP2D6 | |
| SCHEMBL1587530 | 0.84 | CYP2C9 (0.49) | CYP2C9NPSR1GLO1ALDH1A1CYP2D6 | |
| SCHEMBL18936345 | 0.84 | CYP2C9 (0.43) | CYP2C9NPSR1GLO1ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009642-A1 | Method for the Regioselective Synthesis of 1-Alkyl-3-haloalkyl-pyrazole-4-carboxylic Acid Derivatives | BAYER CROPSCIENCE AG (DE) | 2011-01-13 | — | — | US | claimed |
| EP-3178813-A1 | METHOD FOR PREPARING HALOGENATED 3-OXOCARBOXYLATES CARRYING A 2-ALKOXYMETHYLIDENE OR A 2-DIALKYLAMINOMETHYLIDENE GROUP | BASF SE (DE) | 2017-06-14 | — | — | EP | disclosed |
| US-9012657-B2 | Method for producing pyrazole compound | CENTRAL GLASS COMPANY, LIMITED (JP) | 2015-04-21 | — | — | US | disclosed |
| US-20140107347-A1 | Method for Producing Pyrazole Compound | CENTRAL GLASS COMPANY, LIMITED (JP) | 2014-04-17 | — | — | US | disclosed |
| US-8629288-B2 | Method for the regioselective synthesis of 1-alky1-3-haloalkyl-pyrazole-4-carboxylic acid derivatives | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-01-14 | — | — | US | disclosed |
| US-8592605-B2 | Method for the regioselective synthesis of 1-Alkyl-3-haloalkyl-pyrazole-4-carboxylic acid derivatives | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-11-26 | — | — | US | disclosed |
| US-20130197239-A1 | Method for the Regioselective Synthesis of 1-Alkyl-3-Haloalkyl-Pyrazole-4-Carboxylic Acid Derivatives | BAYER CROPSCIENCE AG (DE) | 2013-08-01 | — | — | US | disclosed |
| US-8288582-B2 | Method for the production of 2-fluoroacyl-3-aminoacrylic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2012-10-16 | — | — | US | disclosed |
| US-8258335-B2 | Process for preparing 2-dihaloacyl-3-aminoacrylic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2012-09-04 | — | — | US | disclosed |
| US-20110009642-A1 | Method for the Regioselective Synthesis of 1-Alkyl-3-haloalkyl-pyrazole-4-carboxylic Acid Derivatives | BAYER CROPSCIENCE AG (DE) | 2011-01-13 | — | — | US | disclosed |
| EP-1678119-B1 | METHOD FOR PRODUCING 2-DIHALOACYL-3-AMINO-ACRYLIC ACID ESTERS AND 3-DIHALOMETHYL-PYRAZOLE-4-CARBOXYLIC ACID ESTERS | BAYER CROPSCIENCE AG (DE) | 2011-01-05 | — | — | EP | disclosed |
| US-20100274049-A1 | Method for the production of 2-fluoroacyl-3-aminoacrylic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2010-10-28 | — | — | US | disclosed |
| US-20100204483-A1 | PROCESS FOR PREPARING 2-DIHALOACYL-3-AMINOACRYLIC ACID DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2010-08-12 | — | — | US | disclosed |
| US-7358387-B2 | Method for producing 2-dihaloacyl-3-amino-acrylic acid esters and 3-dihalomethyl pyrazole-4-carboxylic acid esters | BAYER CROPSCIENCE AG (DE) | 2008-04-15 | — | — | US | disclosed |
| US-7358387-B2 | Method for producing 2-dihaloacyl-3-amino-acrylic acid esters and 3-dihalomethyl pyrazole-4-carboxylic acid esters | BAYER CROPSCIENCE AG (DE) | 2008-04-15 | — | — | US | disclosed |
| US-20060252944-A1 | Method for producing 2-dihaloacyl-3-amino-acrylic acid esters and 3-dihalomethyl pyrazole-4-carboxylic acid esters | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2006-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140107347-A1 | Method for Producing Pyrazole Compound | AADAC, ALDH7A1, AADAT | CYP2C9 60/4885NPSR1 4089/4885GLO1 319/4885 |
| US-20110009642-A1 | Method for the Regioselective Synthesis of 1-Alkyl-3-haloalkyl-pyrazole-4-carboxylic Acid Derivatives | ATL3, HCAR3, AADAC | CYP2C9 422/4885NPSR1 2992/4885GLO1 1936/4885 |
| US-20100204483-A1 | PROCESS FOR PREPARING 2-DIHALOACYL-3-AMINOACRYLIC ACID DERIVATIVES | AADAT, DDC, IDUA | CYP2C9 1949/4885NPSR1 2213/4885GLO1 1177/4885 |
| US-20100274049-A1 | Method for the production of 2-fluoroacyl-3-aminoacrylic acid derivatives | AADAT, AADAC, ALAD | CYP2C9 1453/4885NPSR1 2981/4885GLO1 304/4885 |
| US-20130197239-A1 | Method for the Regioselective Synthesis of 1-Alkyl-3-Haloalkyl-Pyrazole-4-Carboxylic Acid Derivatives | ATL3, HCAR3, AADAC | CYP2C9 422/4885NPSR1 2992/4885GLO1 1936/4885 |
| US-20060252944-A1 | Method for producing 2-dihaloacyl-3-amino-acrylic acid esters and 3-dihalomethyl pyrazole-4-carboxylic acid esters | DDC, IDUA, AADAT | CYP2C9 503/4885NPSR1 3425/4885GLO1 1498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.