Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylic Acid SCHEMBL8927624 | 0.94 | LMNA (0.48) | LMNATP53ALDH1A1CYP3A4MAPK1 | |
| Acrylic Acid SCHEMBL2688353 | 0.94 | LMNA (0.48) | LMNATP53ALDH1A1CYP3A4MAPK1 | |
| Acrylic Acid SCHEMBL6685086 | 0.94 | LMNA (0.48) | LMNATP53ALDH1A1CYP3A4MAPK1 | |
| Acrylic Acid SCHEMBL5694042 | 0.94 | LMNA (0.48) | LMNATP53ALDH1A1CYP3A4MAPK1 | |
| Acrylic Acid SCHEMBL2470338 | 0.94 | LMNA (0.48) | LMNATP53ALDH1A1CYP3A4MAPK1 | |
| Acrylic Acid SCHEMBL898587 | 0.94 | LMNA (0.48) | LMNATP53ALDH1A1CYP3A4MAPK1 | |
| Acrylic Acid SCHEMBL899017 | 0.94 | LMNA (0.48) | LMNATP53ALDH1A1CYP3A4MAPK1 | |
| Acrylic Acid SCHEMBL134219 | 0.94 | LMNA (0.48) | LMNATP53ALDH1A1CYP3A4MAPK1 | |
| Acrylic Acid SCHEMBL5933800 | 0.94 | LMNA (0.48) | LMNATP53ALDH1A1CYP3A4MAPK1 | |
| Acrylic Acid SCHEMBL28238860 | 0.94 | LMNA (0.48) | LMNATP53ALDH1A1CYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5096767-A | Containing radiation curable polymer | MITSUBISHI PAPER MILLS LIMITED (JP) | 1992-03-17 | — | — | US | disclosed |