Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
| ▸ | FNTB | P49356 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.38 |
| ▸ | AR | P10275 | 5/20 | 0.37 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8203795 | 0.92 | NFKB1 (0.44) | ALDH1A1TSHRNFKB1NFKB2RELA | |
| SCHEMBL10623020 | 0.90 | ALDH1A1 (0.54) | ALDH1A1TSHRNFKB1NFKB2RELA | |
| SCHEMBL8470203 | 0.89 | NFKB1 (0.46) | ALDH1A1TSHRNFKB1NFKB2RELA | |
| SCHEMBL8470202 | 0.89 | NFKB1 (0.46) | ALDH1A1TSHRNFKB1NFKB2RELA | |
| SCHEMBL10419014 | 0.89 | NFKB1 (0.54) | ALDH1A1TSHRNFKB1NFKB2RELA | |
| SCHEMBL9619163 | 0.89 | NFKB1 (0.54) | ALDH1A1TSHRNFKB1NFKB2RELA | |
| SCHEMBL8207710 | 0.89 | NFKB1 (0.54) | ALDH1A1TSHRNFKB1NFKB2RELA | |
| SCHEMBL8192700 | 0.89 | NFKB1 (0.54) | ALDH1A1TSHRNFKB1NFKB2RELA | |
| SCHEMBL3083179 | 0.89 | NFKB1 (0.54) | ALDH1A1TSHRNFKB1NFKB2RELA | |
| SCHEMBL7565596 | 0.89 | NFKB1 (0.54) | ALDH1A1TSHRNFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276393-B1 | PROCESS FOR THE PREPARATION OF 6-ALPHA, 9-ALPHA-DIFLUORO-11-BETA-17-ALPHA-DIHYDROXY-16-ALPHA-METHYL-PREGN-4-ENE-3,20-DIONE AND ITS DERIVATIVES | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-03-04 | — | — | EP | claimed |
| US-4898693-A | Process for production of 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-4-pregnene-3,20-dione and its derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-02-06 | — | — | US | claimed |
| EP-0276393-A2 | Process for the preparation of 6-alpha, 9-alpha-difluoro-11-beta-17-alpha-dihydroxy-16-alpha-methyl-pregn-4-ene-3,20-dione and its derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-08-03 | — | — | EP | claimed |
| EP-0276393-B1 | PROCESS FOR THE PREPARATION OF 6-ALPHA, 9-ALPHA-DIFLUORO-11-BETA-17-ALPHA-DIHYDROXY-16-ALPHA-METHYL-PREGN-4-ENE-3,20-DIONE AND ITS DERIVATIVES | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-03-04 | — | — | EP | disclosed |
| US-4898693-A | Process for production of 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-4-pregnene-3,20-dione and its derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-02-06 | — | — | US | disclosed |
| EP-0276393-A2 | Process for the preparation of 6-alpha, 9-alpha-difluoro-11-beta-17-alpha-dihydroxy-16-alpha-methyl-pregn-4-ene-3,20-dione and its derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-08-03 | — | — | EP | disclosed |