Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10872651 | 0.99 | KCNMA1 (0.46) | KCNMA1RAB9AKMT2AMEN1SLC9A1 | |
| SCHEMBL3186989 | 0.84 | KCNMA1 (0.52) | KCNMA1RAB9AKMT2AMEN1SLC9A1 | |
| SCHEMBL8067247 | 0.81 | KCNMA1 (0.47) | KCNMA1SLC9A1SMN1; SMN2TSHR | |
| SCHEMBL9437960 | 0.81 | KCNMA1 (0.46) | KCNMA1RAB9AKMT2AMEN1SLC9A1 | |
| SCHEMBL5814955 | 0.80 | SLC9A1 (0.45) | KCNMA1SLC9A1SMN1; SMN2TSHRGAA | |
| SCHEMBL8849637 | 0.79 | KCNMA1 (0.47) | KCNMA1RAB9AKMT2AMEN1SLC9A1 | |
| SCHEMBL8849556 | 0.79 | KCNMA1 (0.47) | KCNMA1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3185152 | 0.75 | KCNMA1 (0.51) | KCNMA1RAB9AKMT2AMEN1SLC9A1 | |
| SCHEMBL3179989 | 0.73 | KCNMA1 (0.51) | KCNMA1RAB9AKMT2AMEN1SLC9A1 | |
| Iodide SCHEMBL9627643 | 0.73 | LMNA (0.34) | KCNMA1RAB9AKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0188236-B1 | POLYACETAL RESIN COMPOSITIONS HAVING IMPROVED RESISTANCE TO DETERIORATION WHEN EXPOSED TO LIGHT AND CONTAINING ALKYLIDENE BIS(BENZOTRIAZOLYL PHENOLS) | ADEKA ARGUS CHEMICAL CO., Ltd. (JP) | 1992-04-01 | — | — | EP | disclosed |
| EP-0180993-B1 | PROCESS FOR PREPARING 2,2'-METHYLENE-BIS-(4-HYDROCARBYL-6-BENZO-TRIAZOLYLPHENOLS) | ADEKA ARGUS CHEMICAL CO., Ltd. (JP) | 1991-02-27 | — | — | EP | disclosed |
| EP-0180992-B1 | STABILIZER COMPOSITIONS FOR SYNTHETIC RESINS IMPARTING IMPROVED LIGHT STABILITY | ADEKA ARGUS CHEMICAL CO., Ltd. (JP) | 1990-07-11 | — | — | EP | disclosed |
| US-4937348-A | Process for preparing 2,2'-methylene-bis-(4-hydrocarbyl-6-benzotriazolylphenols) | ADEKA ARGUS CHEMICAL CO., LTD. (JP) | 1990-06-26 | — | — | US | disclosed |
| US-4871793-A | Polyphenylene sulfide resin compositions having improved resistance to deterioration when exposed to light and containing alkylidene bis (benzotriazolylphenols) | NAKAHARA YUTAKA (JP) | 1989-10-03 | — | — | US | disclosed |
| US-4812498-A | Polycarbonate resin compositions having improved resistance to deterioration when exposed to light and containing alkylidene bis(benzotriazolyl phenols) | ADEKA ARGUS CHEMICAL CO., LTD. (JP) | 1989-03-14 | — | — | US | disclosed |
| US-4684679-A | DISCOLORATION INHIBITION | ADEKA ARGUS CHEMICAL CO., LTD. (JP) | 1987-08-04 | — | — | US | disclosed |
| US-4684680-A | BENZOTRIAZOLYL PHENOL STABILIZER | ADEKA ARGUS CHEMICAL CO., LTD. (JP) | 1987-08-04 | — | — | US | disclosed |
| US-4681905-A | 2,2,6,6-TETRAMETHYLPIPERIDYL COMPOUND, AND AN ALKYLIDENE-BIS-(BENZOTRIAZOLYL PHENYL) | ADEKA ARGUS CHEMICAL CO., LTD. (JP) | 1987-07-21 | — | — | US | disclosed |
| EP-0180991-A2 | Thermosetting synthetic resin lacquer compositions having improved light stability | ADEKA ARGUS CHEMICAL CO., Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |
| EP-0180993-A2 | Process for preparing 2,2'-methylene-bis-(4-hydrocarbyl-6-benzo-triazolylphenols) | ADEKA ARGUS CHEMICAL CO., Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |