Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3975746 | 0.91 | TDP1 (0.46) | TDP1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL3080153 | 0.84 | TDP1 (0.48) | TDP1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL1437603 | 0.81 | ALDH1A1 (0.43) | TDP1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL1292730 | 0.80 | TDP1 (0.50) | TDP1ALDH1A1MEN1KMT2ACHRM1 | |
| SCHEMBL8160913 | 0.80 | TDP1 (0.42) | TDP1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL9259126 | 0.80 | GABRR1 (0.46) | TDP1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL28259406 | 0.78 | GPR84 (0.50) | TDP1MEN1KMT2AMAPK1 | |
| SCHEMBL7056634 | 0.78 | L3MBTL1 (0.53) | TDP1ALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL30371946 | 0.78 | ALDH1A1 (0.46) | TDP1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL663775 | 0.78 | ALDH1A1 (0.46) | TDP1ALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1023404-C | Process for producing benzopyran derivative | HOFFMANN LA ROCHE (CH) | 1994-01-05 | — | — | CN | disclosed |
| US-5118694-A | Hypotensive agents; treatment for cardiovascular and muscular disorders | HOFFMANN-LA ROCHE INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-4971982-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, SMOOTH MUSCLE DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1990-11-20 | — | — | US | disclosed |
| CN-1030582-A | 1-benzopyran derivatives | HOFFMANN LA ROCHE (CH) | 1989-01-25 | — | — | CN | disclosed |