Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 10/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 4/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9629884 | 0.90 | ACHE (0.45) | ACHENQO2MTNR1AMTNR1B | |
| SCHEMBL9627778 | 0.85 | MCHR1 (0.48) | ACHEADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL9627883 | 0.82 | ACHE (0.45) | ACHENQO2MTNR1AMTNR1B | |
| SCHEMBL10458915 | 0.81 | KMT2A (0.45) | ACHE | |
| SCHEMBL9628081 | 0.81 | ACHE (0.60) | ACHE | |
| SCHEMBL9628479 | 0.80 | ACHE (0.44) | ACHENQO2MTNR1AMTNR1B | |
| SCHEMBL9628568 | 0.80 | PTGS2 (0.43) | ACHENQO2MTNR1AMTNR1B | |
| SCHEMBL9628113 | 0.77 | MTNR1A (0.53) | NQO2MTNR1AMTNR1B | |
| SCHEMBL9628591 | 0.73 | ACHE (0.47) | ACHENQO2MTNR1AMTNR1B | |
| SCHEMBL9628952 | 0.73 | ACHE (0.66) | ACHENQO2MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0281261-B1 | 3-AMINOMETHYL DERIVATIVES OF INDANE, INDOLINE AND DIHYDROBENZOFURANE AND DIHYDROBENZOTHIOPHENE | H. LUNDBECK A/S (DK) | 1992-05-06 | — | — | EP | disclosed |
| US-4946863-A | CNS-affecting 6-oxy-3-aminomethyl indanes, compositions thereof, and method of treating therewith | H. LUNDBECK A/S (DK) | 1990-08-07 | — | — | US | disclosed |
| US-4847254-A | CNS affecting 5-oxy-3-aminomethyl-dihydro-benzofurans and benzothiophenes | H. LUNDBECK A/S (DK) | 1989-07-11 | — | — | US | disclosed |
| EP-0281261-A2 | 3-Aminomethyl derivatives of indane, indoline and dihydrobenzofurane and dihydrobenzothiophene | H. LUNDBECK A/S (DK) | 1988-09-07 | — | — | EP | disclosed |