Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524497 | 0.87 | GRM5 (0.39) | PDE4APDE4BPDE4CPDE4DKDM1A | |
| SCHEMBL9528002 | 0.86 | KDM1A (0.36) | PDE4APDE4BPDE4CPDE4DKDM1A | |
| SCHEMBL9525564 | 0.86 | KDM1A (0.36) | PDE4APDE4BPDE4CPDE4DKDM1A | |
| SCHEMBL9524637 | 0.86 | GRM5 (0.39) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL9527764 | 0.83 | RARA (0.40) | PDE4APDE4BPDE4CPDE4DKDM1A | |
| SCHEMBL9527814 | 0.83 | PDE4A (0.34) | PDE4APDE4BPDE4CPDE4DKDM1A | |
| SCHEMBL9525005 | 0.83 | GABRA1 (0.38) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL9523558 | 0.82 | RARA (0.42) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| Hydrochloric Acid SCHEMBL9627192 | 0.82 | PDE4A (0.34) | PDE4APDE4BPDE4CPDE4DKDM1A | |
| SCHEMBL9527648 | 0.82 | ABCC9 (0.39) | PDE4APDE4BPDE4CPDE4DABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5118694-A | Hypotensive agents; treatment for cardiovascular and muscular disorders | HOFFMANN-LA ROCHE INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-4971982-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, SMOOTH MUSCLE DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1990-11-20 | — | — | US | disclosed |