Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.56 |
| ▸ | HTT | P42858 | 5/20 | 0.56 |
| ▸ | MITF | O75030 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | IDO1 | P14902 | 1/20 | 0.56 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.56 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.56 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.56 |
| ▸ | HKDC1 | Q2TB90 | 3/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.47 |
| ▸ | TDP2 | O95551 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10953110 | 0.89 | IDO1 (0.52) | MAPTHTTMITFALDH1A1LMNA | |
| SCHEMBL9627850 | 0.87 | PTPN1 (0.51) | MAPTHTTMITFALDH1A1LMNA | |
| SCHEMBL10956573 | 0.86 | PTPN1 (0.54) | MAPTHTTMITFALDH1A1LMNA | |
| SCHEMBL9627508 | 0.86 | PTPN1 (0.54) | MAPTHTTMITFALDH1A1LMNA | |
| SCHEMBL10954496 | 0.86 | PTPN1 (0.54) | MAPTHTTMITFALDH1A1LMNA | |
| SCHEMBL14307223 | 0.86 | CDC25B (0.50) | MAPTHTTMITFALDH1A1LMNA | |
| SCHEMBL9627696 | 0.84 | IDO1 (0.60) | MAPTHTTMITFALDH1A1LMNA | |
| SCHEMBL9627459 | 0.82 | S100A4 (0.50) | MAPTHTTMITFALDH1A1LMNA | |
| SCHEMBL9627527 | 0.82 | S100A4 (0.50) | MAPTHTTMITFALDH1A1LMNA | |
| SCHEMBL9628399 | 0.81 | MAOA (0.50) | MAPTHTTMITFALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155132-A | Nonsteroidal antiinflammatory agents; treating psoriasis | SYNTEX (U.S.A.) INC. (US) | 1992-10-13 | — | — | US | disclosed |
| US-5134161-A | Enzyme inhibitors for skin disorders, antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-07-28 | — | — | US | disclosed |
| US-5089657-A | Topical antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-02-18 | — | — | US | disclosed |
| US-4786652-A | TOPICAL ADMINISTRATION | SYNTEX (U.S.A.) INC. (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0282056-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| US-4758587-A | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-07-19 | — | — | US | disclosed |
| US-4507241-A | Method for the hydrocarbylation of naphthoquinone derivatives | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-03-26 | — | — | US | disclosed |