Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | STAT6 | P42226 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9628774 | 0.91 | APLNR (0.31) | APLNR | |
| SCHEMBL8959112 | 0.83 | — | — | |
| Bicarbonate SCHEMBL10606382 | 0.81 | MAPK1 (0.33) | MAPK1SMN1; SMN2TP53NFKB1CYP2C19 | |
| Bicarbonate SCHEMBL10865371 | 0.79 | MAPK1 (0.32) | MAPK1SMN1; SMN2TP53NFKB1CYP2C19 | |
| Bicarbonate SCHEMBL10608931 | 0.79 | MAPK1 (0.32) | MAPK1SMN1; SMN2TP53NFKB1CYP2C19 | |
| SCHEMBL1930203 | 0.77 | MAPK1 (0.36) | MAPK1SMN1; SMN2TP53NFKB1CYP2C19 | |
| SCHEMBL9640786 | 0.77 | MAPK1 (0.41) | MAPK1SMN1; SMN2TP53NFKB1CYP2C19 | |
| SCHEMBL9640788 | 0.77 | MAPK1 (0.41) | MAPK1SMN1; SMN2TP53NFKB1CYP2C19 | |
| Hydrochloric Acid SCHEMBL9639877 | 0.75 | MAPK1 (0.39) | MAPK1SMN1; SMN2TP53NFKB1CYP2C19 | |
| Fluoride SCHEMBL10972490 | 0.75 | MAPK1 (0.39) | MAPK1SMN1; SMN2TP53NFKB1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0257448-B1 | OPTICALLY ACTIVE CYCLOPROPANECARBOXAMIDES | NIHON BAYER AGROCHEM K.K. (JP) | 1992-03-11 | — | — | EP | disclosed |
| EP-0170842-B1 | N-BENZYLCYCLOPROPANECARBOXAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND FUNGICIDES FOR AGRICULTURE AND HORTICULTURE | NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) | 1989-09-13 | — | — | EP | disclosed |
| EP-0257448-A2 | Optically active cyclopropanecarboxamides | NIHON BAYER AGROCHEM K.K. (JP) | 1988-03-02 | — | — | EP | disclosed |