Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9767569 | 0.87 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2ALOX15TSHRMEN1 | |
| SCHEMBL9533735 | 0.83 | LMNA (0.36) | MAPTPOLBKDM4EL3MBTL1NPSR1 | |
| SCHEMBL9352368 | 0.74 | PGR (0.42) | MAPTPOLBKDM4EL3MBTL1NPSR1 | |
| SCHEMBL9629185 | 0.71 | PGR (0.36) | MAPTPOLBKDM4EL3MBTL1NPSR1 | |
| SCHEMBL9533850 | 0.70 | ALDH1A1 (0.33) | ALDH1A1P2RX7LMNA | |
| SCHEMBL9469933 | 0.69 | PGR (0.60) | MAPTPOLBKDM4EL3MBTL1NPSR1 | |
| SCHEMBL9469283 | 0.66 | ALDH1A1 (0.39) | MAPTPOLBKDM4EL3MBTL1NPSR1 | |
| SCHEMBL5251844 | 0.65 | MEN1 (0.45) | MAPTPOLBKDM4EL3MBTL1NPSR1 | |
| SCHEMBL9767646 | 0.64 | ALDH1A1 (0.34) | POLBALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL9348203 | 0.64 | NPC1 (0.40) | MAPTPOLBKDM4EL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0241291-B1 | ARYL-SUBSTITUTED NAPHTHYRIDINE AND PYRIDOPYRAZINE DERIVATIVES | SCHERING CORPORATION (US) | 1993-06-02 | — | — | EP | disclosed |
| US-5011860-A | Aryl-substituted naphthyridine and pyridopyrazine derivatives and their use in treating hyperproliferative skin diseases | SCHERING CORPORATION (US) | 1991-04-30 | — | — | US | disclosed |
| US-4882332-A | Immune suppression method employing arly-substituted naphthyridine and pyridopyrazine derivatives | SCHERING CORPORATION (US) | 1989-11-21 | — | — | US | disclosed |
| US-4866061-A | TREATMENT OF ALLERGIC REACTIONS, ULCERS, INFLAMMATION | SCHERING CORPORATION (US) | 1989-09-12 | — | — | US | disclosed |
| US-4760073-A | Aryl-substituted naphthyridine and pyridopyrazine derivatives, useful as anti-allergic agents | SCHERING CORPORATION (US) | 1988-07-26 | — | — | US | disclosed |
| EP-0241291-A2 | Aryl-substituted naphthyridine and pyridopyrazine derivatives | SCHERING CORPORATION (US) | 1987-10-14 | — | — | EP | disclosed |