Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.40 |
| ▸ | KCNH2 known ✓ | Q12809 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.35 |
| ▸ | EED | O75530 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688954 | 0.96 | MEN1 (0.42) | MEN1KMT2ATP53MAPTALDH1A1 | |
| Fumaric Acid SCHEMBL9629725 | 0.89 | MEN1 (0.41) | MEN1KMT2ATP53MAPTALDH1A1 | |
| Fumaric Acid SCHEMBL9879661 | 0.88 | MEN1 (0.40) | MEN1KMT2ATP53MAPTALDH1A1 | |
| SCHEMBL9690678 | 0.87 | MEN1 (0.39) | MEN1KMT2ATP53MAPTALDH1A1 | |
| Fumaric Acid SCHEMBL9630404 | 0.86 | SLC6A9 (0.43) | TP53MAPTENPP2 | |
| Fumaric Acid SCHEMBL9879818 | 0.85 | MEN1 (0.39) | MEN1KMT2ATP53MAPTALDH1A1 | |
| Fumaric Acid SCHEMBL9629599 | 0.85 | MAPK1 (0.36) | MEN1KMT2AMAPTALDH1A1ENPP2 | |
| SCHEMBL9630210 | 0.84 | EED (0.39) | MEN1KMT2ATP53MAPTALDH1A1 | |
| Oxalic Acid SCHEMBL9687737 | 0.82 | MEN1 (0.42) | MEN1KMT2ATP53MAPTALDH1A1 | |
| Oxalic Acid SCHEMBL9687735 | 0.82 | MEN1 (0.42) | MEN1KMT2ATP53MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151424-A | Antiallergens or antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-29 | — | — | US | disclosed |
| US-5071846-A | Anti-hystaminic [(bicyclic heterocyclyl) methyl and --hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-12-10 | — | — | US | disclosed |
| US-4988689-A | Antiallergens, antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-01-29 | — | — | US | disclosed |