Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 10/20 | 0.40 |
| ▸ | TP53 | P04637 | 11/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PYGM | P11217 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9690741 | 0.96 | SLC6A9 (0.46) | SLC6A9ENPP2MAPTTP53POLB | |
| Fumaric Acid SCHEMBL9630608 | 0.92 | SLC6A9 (0.43) | SLC6A9ENPP2MAPTTP53POLB | |
| SCHEMBL9691136 | 0.86 | SLC6A9 (0.44) | SLC6A9ENPP2MAPTTP53POLB | |
| Fumaric Acid SCHEMBL9629247 | 0.86 | MEN1 (0.40) | ENPP2MAPTTP53 | |
| SCHEMBL9690993 | 0.84 | SLC6A9 (0.46) | SLC6A9ENPP2MAPTTP53POLB | |
| SCHEMBL9629312 | 0.83 | SLC6A9 (0.47) | SLC6A9ENPP2MAPTTP53POLB | |
| SCHEMBL9629392 | 0.81 | TP53 (0.40) | ENPP2MAPTTP53LMNA | |
| SCHEMBL9688954 | 0.81 | MEN1 (0.42) | ENPP2MAPTTP53 | |
| SCHEMBL9564788 | 0.80 | ALDH1A1 (0.38) | SLC6A9MAPTTP53LMNA | |
| Fumaric Acid SCHEMBL9629590 | 0.79 | SSTR5 (0.46) | MAPTTP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151424-A | Antiallergens or antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-29 | — | — | US | disclosed |
| US-5071846-A | Anti-hystaminic [(bicyclic heterocyclyl) methyl and --hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-12-10 | — | — | US | disclosed |
| US-4988689-A | Antiallergens, antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-01-29 | — | — | US | disclosed |