Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9657975 | 0.87 | ALOX5 (0.54) | KDM4EALDH1A1HPGDHSD17B10ALOX5 | |
| SCHEMBL9627705 | 0.87 | KDM4E (0.46) | KDM4EALDH1A1HPGDHSD17B10ALOX5 | |
| SCHEMBL9656389 | 0.86 | ALOX5 (0.56) | KDM4EALDH1A1HPGDHSD17B10ALOX5 | |
| SCHEMBL9627928 | 0.82 | KDM4E (0.47) | KDM4EALDH1A1HPGDHSD17B10ALOX5 | |
| SCHEMBL9657122 | 0.81 | KDM4E (0.47) | KDM4EALDH1A1HPGDHSD17B10ALOX5 | |
| SCHEMBL5588414 | 0.80 | ALOX5 (0.54) | KDM4EALDH1A1HPGDHSD17B10ALOX5 | |
| SCHEMBL9628428 | 0.79 | KDM4E (0.46) | KDM4EALDH1A1HPGDHSD17B10ALOX5 | |
| SCHEMBL9659321 | 0.78 | NCEH1 (0.45) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL9456640 | 0.78 | HPGD (0.55) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL9812685 | 0.76 | KDM4E (0.50) | KDM4EALDH1A1HPGDMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155132-A | Nonsteroidal antiinflammatory agents; treating psoriasis | SYNTEX (U.S.A.) INC. (US) | 1992-10-13 | — | — | US | disclosed |
| US-5089657-A | Topical antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| EP-0282056-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| US-4758587-A | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-07-19 | — | — | US | disclosed |