Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CFTR | P13569 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9657975 | 0.88 | ALOX5 (0.54) | KDM4EALDH1A1HPGDGAACFTR | |
| SCHEMBL9656389 | 0.87 | ALOX5 (0.56) | KDM4EALDH1A1HPGDGAACFTR | |
| SCHEMBL9656088 | 0.85 | KDM4E (0.46) | KDM4EALDH1A1HPGDMAPK1SMN1; SMN2 | |
| SCHEMBL9656957 | 0.84 | ALDH1A1 (0.46) | KDM4EALDH1A1HPGDCYP1A2GLA | |
| SCHEMBL9656973 | 0.83 | KDM4E (0.45) | KDM4EALDH1A1HPGDCYP1A2GLA | |
| SCHEMBL9657719 | 0.82 | LDHA (0.49) | KDM4EALDH1A1HPGDCYP3A4ALOX5 | |
| SCHEMBL9627705 | 0.81 | KDM4E (0.46) | KDM4EALDH1A1HPGDMAPK1SMN1; SMN2 | |
| SCHEMBL9629454 | 0.81 | KDM4E (0.49) | KDM4EALDH1A1HPGDMAPK1SMN1; SMN2 | |
| SCHEMBL9654924 | 0.81 | ABCB11 (0.42) | KDM4EALDH1A1HPGDCFTRALOX5 | |
| SCHEMBL9657723 | 0.81 | ALOX5 (0.38) | KDM4EALDH1A1HPGDALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134161-A | Enzyme inhibitors for skin disorders, antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-07-28 | — | — | US | disclosed |
| US-4786652-A | TOPICAL ADMINISTRATION | SYNTEX (U.S.A.) INC. (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |