Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | VKORC1 | Q9BQB6 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9656088 | 0.87 | KDM4E (0.46) | KDM4EALDH1A1SMN1; SMN2MAPK1SLC2A1 | |
| SCHEMBL9628418 | 0.79 | KDM4E (0.49) | KDM4EALDH1A1SMN1; SMN2MAPK1SLC2A1 | |
| SCHEMBL6917217 | 0.78 | ALDH1A1 (0.40) | KDM4EALDH1A1MAPK1PDE4DCYP1A2 | |
| SCHEMBL18950744 | 0.78 | KDM4E (0.75) | KDM4EALDH1A1SMN1; SMN2MAPK1PDE4A | |
| SCHEMBL9812680 | 0.77 | KDM4E (0.57) | KDM4EALDH1A1SMN1; SMN2MAPK1SLC2A1 | |
| SCHEMBL11036361 | 0.77 | MCL1 (0.35) | KDM4EALDH1A1SMN1; SMN2MAPK1PDE4A | |
| SCHEMBL9657122 | 0.76 | KDM4E (0.47) | KDM4EALDH1A1SMN1; SMN2MAPK1PDE4A | |
| SCHEMBL9627705 | 0.76 | KDM4E (0.46) | KDM4EALDH1A1SMN1; SMN2MAPK1SLC2A1 | |
| SCHEMBL9629454 | 0.76 | KDM4E (0.49) | KDM4EALDH1A1SMN1; SMN2MAPK1SLC2A1 | |
| SCHEMBL9628130 | 0.76 | KDM4E (0.52) | KDM4EALDH1A1SMN1; SMN2MAPK1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0146348-B1 | SUBSTITUTED NAPHTHALENES, INDOLES, BENZOFURANS AND BENZOTHIOPHENES AS LIPOXYGENASE INHIBITORS | THE UPJOHN COMPANY (US) | 1991-07-31 | — | — | EP | claimed |
| US-4737519-A | Substituted naphthalenes, indoles, benzofurans, and benzothiophenes as lipoxygenase inhibitors | THE UPJOHN COMPANY (US) | 1988-04-12 | — | — | US | claimed |
| EP-0146348-A2 | Substituted naphthalenes, indoles, benzofurans and benzothiophenes as lipoxygenase inhibitors | THE UPJOHN COMPANY (US) | 1985-06-26 | — | — | EP | claimed |
| EP-0146348-B1 | SUBSTITUTED NAPHTHALENES, INDOLES, BENZOFURANS AND BENZOTHIOPHENES AS LIPOXYGENASE INHIBITORS | THE UPJOHN COMPANY (US) | 1991-07-31 | — | — | EP | disclosed |
| US-4849442-A | Method for treating or preventing deep vein thrombosis using lipoxygenase inhibitors | THE UPJOHN COMPANY (US) | 1989-07-18 | — | — | US | disclosed |
| US-4849445-A | Method for treating or preventing deep vein thrombosis using lipoxygenase inhibitors | THE UPJOHN COMPANY (US) | 1989-07-18 | — | — | US | disclosed |
| US-4791138-A | SUBSTITUTED NAPHTHALENES | THE UPJOHN COMPANY (US) | 1988-12-13 | — | — | US | disclosed |
| US-4737519-A | Substituted naphthalenes, indoles, benzofurans, and benzothiophenes as lipoxygenase inhibitors | THE UPJOHN COMPANY (US) | 1988-04-12 | — | — | US | disclosed |
| EP-0146348-A2 | Substituted naphthalenes, indoles, benzofurans and benzothiophenes as lipoxygenase inhibitors | THE UPJOHN COMPANY (US) | 1985-06-26 | — | — | EP | disclosed |