Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10746960 | 0.85 | POLB (0.49) | POLBNPC1RAB9AHSP90AA1KMT2A | |
| SCHEMBL28105591 | 0.84 | CA1 (0.50) | HTTNPC1RAB9AHSP90AA1KMT2A | |
| SCHEMBL15881210 | 0.82 | HTT (0.46) | HTTNPC1RAB9AHSP90AA1KMT2A | |
| SCHEMBL9630876 | 0.77 | RAB9A (0.77) | HTTPOLBNPC1RAB9AHSP90AA1 | |
| SCHEMBL10774498 | 0.77 | POLB (0.66) | HTTPOLBRAB9AKMT2AMEN1 | |
| SCHEMBL27145822 | 0.75 | ALDH1A1 (0.47) | HTTPOLBNPC1RAB9AHSP90AA1 | |
| SCHEMBL9262585 | 0.74 | HTT (0.59) | HTTPOLBKMT2AMEN1CYP2C19 | |
| SCHEMBL19442049 | 0.73 | HTT (0.58) | HTTPOLBNPC1RAB9AHSP90AA1 | |
| SCHEMBL9668826 | 0.73 | KMT2A (0.54) | HTTPOLBNPC1RAB9AHSP90AA1 | |
| SCHEMBL7151482 | 0.72 | LOXL2 (0.63) | NPC1RAB9AKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153210-A | Hypoglycemic agent, animal growth regulator; veterinary medicine | BEECHAM GROUP P.L.C. (GB) | 1992-10-06 | — | — | US | disclosed |
| EP-0236624-A2 | Substituted phenyl ethanol amines, processes for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1987-09-16 | — | — | EP | disclosed |