Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.62 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | HCAR3 | P49019 | 7/20 | 0.58 |
| ▸ | CDC25B | P30305 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11269607 | 0.85 | CDC25B (0.78) | MAPK1VCAM1ALDH1A1MAPTHCAR3 | |
| SCHEMBL2426051 | 0.84 | HCAR3 (0.71) | KMT2AMEN1HCAR3LMNA | |
| Methyl Alcohol SCHEMBL28201372 | 0.84 | CDC25B (0.76) | MAPK1VCAM1ALDH1A1MAPTTDP1 | |
| SCHEMBL4281287 | 0.84 | HCAR3 (0.79) | MAPK1VCAM1ALDH1A1MAPTKMT2A | |
| SCHEMBL11150919 | 0.83 | HCAR3 (0.63) | MAPK1VCAM1ALDH1A1MAPTKMT2A | |
| SCHEMBL11014183 | 0.81 | MAPK1 (0.73) | MAPK1VCAM1ALDH1A1MAPTTDP1 | |
| SCHEMBL29117538 | 0.81 | KMT2A (0.59) | MAPK1VCAM1MAPTKMT2AMEN1 | |
| Methyl Alcohol SCHEMBL28201843 | 0.81 | HCAR3 (0.73) | MAPK1VCAM1ALDH1A1MAPTKMT2A | |
| SCHEMBL30590597 | 0.81 | KMT2A (0.59) | MAPK1VCAM1MAPTKMT2AMEN1 | |
| SCHEMBL144666 | 0.80 | MAPK1 (0.77) | MAPK1VCAM1ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0324988-B1 | 4-CHLOR-3-SULFAMOYL BENZOIC ACID HYDRAZIDES, PROCESS FOR THEIR PREPARATION, MEDICINES CONTAINING THEM AND USE OF THESE COMPOUNDS IN THE PREPARATION OF DIURETIC AND SALT REDUCING ACTIVITY MEDICINES | CHINOIN GYOGYSZER ES VEGYESZET (HU) | 1992-04-29 | — | — | EP | disclosed |
| US-4916149-A | Diuretic and saluretic 4-chloro-3-sulfamoylbenzoic acid hydrazides | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1990-04-10 | — | — | US | disclosed |
| CN-1037336-A | Novel 4-chloro-3-sulphonamide benzoyl hydrazine-preparation method contains the drug component and the medical use thereof of this compound | CHINOIN GYOGYSZER ES VEGYESZET (HU) | 1989-11-22 | — | — | CN | disclosed |
| EP-0324988-A1 | 4-Chlor-3-sulfamoyl benzoic acid hydrazides, process for their preparation, medicines containing them and use of these compounds in the preparation of diuretic and salt reducing activity medicines | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1989-07-26 | — | — | EP | disclosed |