Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | NOS2 | P35228 | 1/20 | 0.46 |
| ▸ | SSTR5 | P35346 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PDE6D | O43924 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9629448 | 0.88 | LMNA (0.57) | ALDH1A1LMNAGAASMN1; SMN2KDM4E | |
| SCHEMBL9629294 | 0.86 | LMNA (0.67) | ALDH1A1LMNAGAASMN1; SMN2KDM4E | |
| SCHEMBL9629616 | 0.86 | KDM4E (0.49) | ALDH1A1LMNAGAASMN1; SMN2KDM4E | |
| SCHEMBL9630521 | 0.86 | KDM4E (0.57) | ALDH1A1LMNAGAASMN1; SMN2KDM4E | |
| SCHEMBL9630499 | 0.86 | SMN1; SMN2 (0.51) | ALDH1A1LMNAGAASMN1; SMN2KDM4E | |
| SCHEMBL14173464 | 0.83 | NOS2 (0.56) | ALDH1A1LMNAGAASMN1; SMN2KDM4E | |
| SCHEMBL6995354 | 0.83 | LMNA (0.71) | ALDH1A1LMNAGAASMN1; SMN2KDM4E | |
| SCHEMBL9629456 | 0.82 | KDM4E (0.50) | ALDH1A1LMNAGAASMN1; SMN2KDM4E | |
| SCHEMBL9690656 | 0.82 | ALDH1A1 (0.50) | ALDH1A1LMNAGAASMN1; SMN2KDM4E | |
| SCHEMBL9699749 | 0.82 | KDM4E (0.51) | ALDH1A1LMNAGAASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151424-A | Antiallergens or antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-29 | — | — | US | disclosed |
| EP-0297661-B1 | [(Bicyclic heterocyclyl)methyl and -hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-16 | — | — | EP | disclosed |
| US-5071846-A | Anti-hystaminic [(bicyclic heterocyclyl) methyl and --hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-12-10 | — | — | US | disclosed |
| US-4988689-A | Antiallergens, antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-01-29 | — | — | US | disclosed |