Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10544590 | 0.86 | AKR1C3 (0.46) | PDPK1AKR1C3PARP1MAPTMEN1 | |
| SCHEMBL9142579 | 0.83 | KEAP1 (0.69) | KEAP1PDPK1GRM5AKR1C3IKBKB | |
| Methylene Chloride SCHEMBL11485680 | 0.78 | KEAP1 (0.61) | KEAP1PDPK1GRM5AKR1C3IKBKB | |
| SCHEMBL592670 | 0.75 | MEN1 (0.43) | MEN1NPC1ALDH1A1RAB9AKMT2A | |
| SCHEMBL592680 | 0.75 | LIG1 (0.47) | KEAP1PDPK1PARP1MAPTMEN1 | |
| SCHEMBL6707631 | 0.74 | LTA4H (0.40) | PARP1MAPTMEN1NPC1ALDH1A1 | |
| SCHEMBL593214 | 0.74 | GAA (0.37) | PDPK1PARP1MAPTHPGDGAA | |
| SCHEMBL28310989 | 0.74 | AKR1C3 (0.47) | AKR1C3PARP1MAPTMEN1NPC1 | |
| SCHEMBL593694 | 0.73 | SRD5A2 (0.53) | MAPTALDH1A1RAB9AGAA | |
| SCHEMBL591123 | 0.72 | ALDH1A1 (0.44) | HDAC1HDAC6MAPTMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0258048-B1 | 2-AMINO-3-AROYL-GAMMA-OXOBENZENEBUTANOIC ACIDS AND ESTERS | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1992-03-25 | — | — | EP | disclosed |
| US-4855448-A | ANTIINFLAMMATORY AGENTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-08-08 | — | — | US | disclosed |
| US-4782089-A | ANTIINFLAMMATORY, ANALGESIC | A. H. ROBINS COMPANY, INCORPORATED (US) | 1988-11-01 | — | — | US | disclosed |