Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.36 |
| ▸ | CCR4 | P51679 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9807288 | 1.00 | ALDH1A1 (0.41) | ALDH1A1HPGDMEN1KMT2AENPP2 | |
| Oxalic Acid SCHEMBL9630637 | 0.89 | MEN1 (0.42) | ALDH1A1HPGDMEN1KMT2AENPP2 | |
| Oxalic Acid SCHEMBL9630643 | 0.89 | MEN1 (0.42) | ALDH1A1HPGDMEN1KMT2AENPP2 | |
| Oxalic Acid SCHEMBL9629530 | 0.85 | MEN1 (0.40) | ALDH1A1HPGDMEN1KMT2AENPP2 | |
| Oxalic Acid SCHEMBL9629525 | 0.85 | MEN1 (0.40) | ALDH1A1HPGDMEN1KMT2AENPP2 | |
| Oxalic Acid SCHEMBL9687737 | 0.83 | MEN1 (0.42) | ALDH1A1HPGDMEN1KMT2AENPP2 | |
| SCHEMBL9630539 | 0.83 | NOS2 (0.48) | ALDH1A1HPGDMEN1KMT2AMAPT | |
| Oxalic Acid SCHEMBL9687735 | 0.83 | MEN1 (0.42) | ALDH1A1HPGDMEN1KMT2AENPP2 | |
| SCHEMBL9629623 | 0.82 | WHR1 (0.39) | ALDH1A1HPGDMEN1KMT2ARXFP1 | |
| SCHEMBL9630536 | 0.82 | MEN1 (0.42) | ALDH1A1MEN1KMT2ATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5071846-A | Anti-hystaminic [(bicyclic heterocyclyl) methyl and --hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-12-10 | — | — | US | disclosed |
| US-4988689-A | Antiallergens, antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-01-29 | — | — | US | disclosed |