Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.72 |
| ▸ | DRD4 | P21917 | 7/20 | 0.72 |
| ▸ | DRD2 | P14416 | 6/20 | 0.72 |
| ▸ | HTR2A | P28223 | 6/20 | 0.72 |
| ▸ | HTR7 | P34969 | 6/20 | 0.72 |
| ▸ | DRD3 | P35462 | 6/20 | 0.72 |
| ▸ | HTR2C | P28335 | 5/20 | 0.72 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.68 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.63 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4405017 | 0.84 | THRB (0.65) | HTR1ADRD4DRD2DRD3LMNA | |
| SCHEMBL4519313 | 0.84 | KCNH2 (0.85) | HTR1ADRD4DRD2HTR2AHTR7 | |
| SCHEMBL26107525 | 0.84 | KCNH2 (0.85) | HTR1ADRD4DRD2HTR2AHTR7 | |
| SCHEMBL26108725 | 0.84 | KCNH2 (0.85) | HTR1ADRD4DRD2HTR2AHTR7 | |
| SCHEMBL9631347 | 0.83 | HTR1A (0.79) | HTR1ADRD4DRD2HTR2AHTR7 | |
| SCHEMBL5009465 | 0.83 | HTR1A (0.78) | HTR1ADRD4DRD2HTR2AHTR7 | |
| SCHEMBL16862217 | 0.82 | HTR1A (0.64) | HTR1ADRD4DRD2HTR2AHTR7 | |
| SCHEMBL9492781 | 0.82 | KCNH2 (0.69) | HTR1ADRD4DRD2HTR2AHTR7 | |
| SCHEMBL6989330 | 0.82 | KCNH2 (0.69) | HTR1ADRD4DRD2HTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL26108256 | 0.82 | KCNH2 (0.83) | HTR1ADRD4DRD2HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110059019-A1 | NOVEL ARYL PIPERAZINE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE AND SEROTONIN RECEPTORS | NEUROSEARCH A/S (DK) | 2011-03-10 | — | — | US | claimed |
| EP-2238125-A1 | NOVEL ARYL PIPERAZINE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE AND SEROTONIN RECEPTORS | NeuroSearch A/S (DK) | 2010-10-13 | — | — | EP | claimed |
| WO-2009095438-A1 | NOVEL ARYL PIPERAZINE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE AND SEROTONIN RECEPTORS | NEUROSEARCH A/S (DK) | 2009-08-06 | — | — | WO | claimed |
| US-20110059019-A1 | NOVEL ARYL PIPERAZINE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE AND SEROTONIN RECEPTORS | NEUROSEARCH A/S (DK) | 2011-03-10 | — | — | US | disclosed |
| EP-2238125-A1 | NOVEL ARYL PIPERAZINE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE AND SEROTONIN RECEPTORS | NeuroSearch A/S (DK) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009095438-A1 | NOVEL ARYL PIPERAZINE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE AND SEROTONIN RECEPTORS | NEUROSEARCH A/S (DK) | 2009-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110059019-A1 | NOVEL ARYL PIPERAZINE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE AND SEROTONIN RECEPTORS | HTR3A, HTR2A, HTR5A | HTR1A 5/4885DRD4 23/4885DRD2 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.