Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1189097 | 0.90 | ALOX5 (0.55) | CYP1A2ALOX5PTGS1PTGS2LMNA | |
| SCHEMBL9862861 | 0.84 | GSK3B (0.52) | KMT2AMEN1GSK3BALDH1A1MAPT | |
| SCHEMBL12187574 | 0.83 | ALOX5 (0.47) | ALOX5PTGS1PTGS2LMNARECQL | |
| SCHEMBL9178091 | 0.83 | PTGS2 (0.61) | CYP1A2CYP2C9CYP2C19ALOX5PTGS1 | |
| SCHEMBL9178540 | 0.82 | PTGS2 (0.60) | CYP1A2CYP2C9CYP2C19ALOX5PTGS1 | |
| SCHEMBL27532704 | 0.82 | ALOX5 (0.46) | CYP2C9CYP2C19ALOX5PTGS1PTGS2 | |
| SCHEMBL9911749 | 0.79 | CYP1A2 (0.57) | CYP1A2CYP2C9CYP2C19ALOX5PTGS1 | |
| SCHEMBL30924512 | 0.79 | CYP1A2 (0.57) | CYP1A2CYP2C9CYP2C19ALOX5PTGS1 | |
| SCHEMBL3807174 | 0.79 | CYP1A2 (0.57) | CYP1A2CYP2C9CYP2C19ALOX5PTGS1 | |
| SCHEMBL10268453 | 0.78 | ALOX5 (0.43) | ALOX5PTGS1PTGS2LMNARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5137897-A | Nonsteroidal antiinflammatory agents; therapy for rheumatic diseases | HOECHST AKTIENGESLLSCHAFT (DE) | 1992-08-11 | — | — | US | disclosed |
| EP-0432740-A2 | 2-Substituted 4-(3-alkyl-5-tert.-butyl-4-hydroxy-phenyl)-thiazole, process for their preparation, medicaments containing them and their utilization | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-06-19 | — | — | EP | disclosed |
| US-4940790-A | ANTIINFLAMMATORY AGENTS FOR RHEUMATIC DIORDERS AND PAIN | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-07-10 | — | — | US | disclosed |
| US-4908364-A | Pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-03-13 | — | — | US | disclosed |
| US-4891374-A | INFLAMMATORY RHEUMATIC DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-01-02 | — | — | US | disclosed |