SCHEMBL9632774

SCHEMBL9632774

CCc1ccc(CC)c(C(O)C(N)CC)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.41
KDM4E B2RXH2 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
TRPA1 O75762 1/20 0.36
ALDH1A1 P00352 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
NPC1 O15118 1/20 0.35
LMNA P02545 1/20 0.35
MAPT P10636 1/20 0.35
RAB9A P51151 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
AKR1C3 P42330 1/20 0.33
AKR1C2 P52895 1/20 0.33
BACE1 P56817 1/20 0.33
CYP1A2 P05177 1/20 0.32
CYP2A6 P11509 1/20 0.32
CA2 P00918 1/20 0.31
DAO P14920 1/20 0.30
POLB P06746 1/20 0.30
CYP3A4 P08684 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9198523 0.85 ADRA2A (0.38) MAPK1KDM4ETDP1TRPA1ALDH1A1
SCHEMBL28806591 0.78 NPC1 (0.41) MAPK1TRPA1ALDH1A1SMN1; SMN2NPC1
SCHEMBL9205996 0.77 CYP3A4 (0.43) MAPK1KDM4ETDP1ALDH1A1SMN1; SMN2
SCHEMBL27952976 0.77 TRPA1 (0.42) MAPK1TRPA1ALDH1A1SMN1; SMN2NPC1
SCHEMBL9735383 0.72 CYP1A2 (0.43) MAPK1TDP1TRPA1ALDH1A1SMN1; SMN2
SCHEMBL16959886 0.69 ALDH1A1 (0.40) MAPK1TDP1TRPA1ALDH1A1SMN1; SMN2
SCHEMBL16960900 0.69 TRPA1 (0.38) MAPK1TRPA1ALDH1A1SMN1; SMN2NPC1
SCHEMBL538823 0.67 NPC1 (0.41) MAPK1TDP1TRPA1ALDH1A1SMN1; SMN2
SCHEMBL31206567 0.67 NPC1 (0.41) MAPK1TDP1TRPA1ALDH1A1SMN1; SMN2
SCHEMBL8750519 0.67 ALDH1A1 (0.38) MAPK1TRPA1ALDH1A1SMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5145998-A Reduction of oxime or silyloxime SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1992-09-08 US disclosed
EP-0237305-B1 A METHOD FOR PRODUCING OPTICALLY ACTIVE AMINES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1992-06-03 EP disclosed
EP-0237305-A2 A method for producing optically active amines SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1987-09-16 EP disclosed