Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL9451435 | 0.86 | CYP19A1 (0.42) | BACE1MMP2MMP9CYP19A1TSHR | |
| Dimethylamine SCHEMBL9451428 | 0.83 | TSHR (0.42) | BACE1MMP2MMP9CYP19A1TSHR | |
| SCHEMBL9451425 | 0.81 | DRD2 (0.41) | BACE1MMP2MMP9UTS2RCYP19A1 | |
| SCHEMBL9451432 | 0.78 | BRD4 (0.38) | BACE1MMP2MMP9UTS2RCYP19A1 | |
| SCHEMBL9303403 | 0.70 | SLC6A2 (0.43) | BACE1SLC6A2TSHRMEN1CYP1A2 | |
| Dimethylamine SCHEMBL8424457 | 0.70 | SIGMAR1 (0.36) | BACE1UTS2RCYP19A1KMT2ASLC6A4 | |
| SCHEMBL9666163 | 0.68 | SIGMAR1 (0.35) | BACE1SLC6A2UTS2RKMT2ASLC6A4 | |
| SCHEMBL5307525 | 0.67 | OPRD1 (0.36) | SLC6A2UTS2RMEN1KMT2ASLC6A4 | |
| SCHEMBL1568276 | 0.67 | CYP19A1 (0.68) | BACE1MMP2MMP9CYP19A1TSHR | |
| SCHEMBL9451487 | 0.66 | UTS2R (0.40) | SLC6A2UTS2RCYP19A1KMT2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0298738-B1 | ANTIPSYCHOTIC COMPOSITIONS CONTAINING DIOXOPIPERIDINE DERIVATIVES | BTG INTERNATIONAL LIMITED (GB) | 1992-09-30 | — | — | EP | disclosed |
| EP-0295836-B1 | USE OF DIOXOPIPERIDINE DERIVATIVES FOR THE MANUFACTURE OF TOPICAL MEDICAMENTS AS ANALGESICS | BTG INTERNATIONAL LIMITED (GB) | 1992-09-02 | — | — | EP | disclosed |
| EP-0368645-B1 | MEMORY-ENHANCING COMPOSITIONS CONTAINING DIOXOPIPERIDINE DERIVATIVES | BTG INTERNATIONAL LIMITED (GB) | 1992-08-26 | — | — | EP | disclosed |
| EP-0263594-B1 | ANXIOLYTIC COMPOSITIONS CONTAINING DIOXOPIPERIDINE DERIVATIVES | BTG INTERNATIONAL LIMITED (GB) | 1992-06-24 | — | — | EP | disclosed |