Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 10/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9633818 | 0.98 | NQO2 (0.42) | KMT2ANQO2ATMCYP4A11CYP4F2 | |
| SCHEMBL9634189 | 0.92 | PLA2G4A (0.41) | KMT2AATMMTNR1AMTNR1BCYP1A2 | |
| SCHEMBL9633121 | 0.90 | PLA2G4A (0.42) | KMT2AATMMTNR1AMTNR1BCYP1A2 | |
| SCHEMBL9634320 | 0.88 | CYP1A2 (0.50) | NQO2CYP4A11CYP4F2MTNR1AMTNR1B | |
| SCHEMBL9634990 | 0.84 | — | — | |
| SCHEMBL9633779 | 0.83 | CYSLTR2 (0.46) | — | |
| SCHEMBL9633723 | 0.82 | — | — | |
| SCHEMBL9633677 | 0.80 | P4HB (0.38) | KMT2ANQO2ATMMTNR1AALDH1A1 | |
| SCHEMBL9633679 | 0.80 | P4HB (0.38) | KMT2ANQO2ATMMTNR1AALDH1A1 | |
| SCHEMBL9633717 | 0.80 | KMT2A (0.46) | KMT2ANQO2MTNR1AMTNR1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0337765-B1 | ACYLSULFONAMIDE DERIVATIVES OF ALPHA-CARBOCYCLYLTOLUIC ACIDS USED AS LEUKOTRIENE ANTAGONISTS | ICI AMERICAS INC. (US) | 1992-10-14 | — | — | EP | disclosed |
| US-5095038-A | Antiinflammatory, antiallergens | ICI AMERICAS INC. (US) | 1992-03-10 | — | — | US | disclosed |
| EP-0337765-A2 | Acylsulfonamide derivatives of alpha-carbocyclyltoluic acids used as leukotriene antagonists | ICI AMERICAS INC. (US) | 1989-10-18 | — | — | EP | disclosed |