Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9685827 | 0.93 | SLC6A9 (0.54) | CHRM5CHRM1SLC6A9TP53KMT2A | |
| Fumaric Acid SCHEMBL9635958 | 0.90 | SLC6A9 (0.62) | CHRM5CHRM1SLC6A9TP53KMT2A | |
| Fumaric Acid SCHEMBL9635941 | 0.88 | CHRM5 (0.53) | CHRM5CHRM1SLC6A9TP53KMT2A | |
| Fumaric Acid SCHEMBL9634773 | 0.87 | SLC6A9 (0.58) | CHRM5CHRM1SLC6A9KMT2AMEN1 | |
| Fumaric Acid SCHEMBL9635828 | 0.87 | SLC6A9 (0.58) | CHRM5CHRM1SLC6A9TP53KMT2A | |
| Fumaric Acid SCHEMBL9634661 | 0.84 | SLC6A9 (0.62) | CHRM5CHRM1SLC6A9TP53KMT2A | |
| Fumaric Acid SCHEMBL9878012 | 0.81 | SLC6A9 (0.61) | CHRM5CHRM1SLC6A9TP53KMT2A | |
| Fumaric Acid SCHEMBL9634676 | 0.81 | SLC6A9 (0.56) | CHRM5CHRM1SLC6A9TP53KMT2A | |
| Fumaric Acid SCHEMBL9634770 | 0.81 | SLC6A9 (0.58) | CHRM5CHRM1SLC6A9TP53KMT2A | |
| SCHEMBL9686512 | 0.81 | SLC6A9 (0.68) | CHRM5CHRM1SLC6A9KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5086056-A | Treating allergic diseases | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-02-04 | — | — | US | disclosed |
| US-4946843-A | ANTIALLERGENS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-08-07 | — | — | US | disclosed |