Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TOP1 | P11387 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.37 |
| ▸ | GUSB | P08236 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634508 | 0.86 | KDM4E (0.60) | ALDH1A1KDM4EHPGDTOP1TOP2A | |
| SCHEMBL9634345 | 0.86 | KDM4E (0.60) | ALDH1A1KDM4EHPGDTOP1TOP2A | |
| SCHEMBL9636115 | 0.85 | MAOB (0.48) | ALDH1A1KDM4EHPGDTOP1TOP2A | |
| SCHEMBL9634280 | 0.85 | MAOB (0.48) | ALDH1A1KDM4EHPGDTOP1TOP2A | |
| SCHEMBL9635537 | 0.82 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDTOP1TOP2A | |
| SCHEMBL9636316 | 0.81 | CYP1A1 (0.55) | ALDH1A1KDM4EHPGDTOP1TOP2A | |
| SCHEMBL9634554 | 0.80 | CDK4 (0.40) | ALDH1A1KDM4EHPGDTOP1TOP2A | |
| SCHEMBL9634643 | 0.80 | MAOB (0.49) | ALDH1A1KDM4EHPGDTOP1TOP2A | |
| SCHEMBL9634352 | 0.79 | AURKA (0.48) | MGAMGAASIMGAM2PARP1 | |
| SCHEMBL9635821 | 0.79 | CYP1A1 (0.38) | KDM4ETOP1TOP2AMGAMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |