Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.66 |
| ▸ | GBA1 | P04062 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5084593 | 0.83 | ACHE (0.69) | ACHEHTR1AHTR2AHTR7DRD3 | |
| SCHEMBL11231683 | 0.82 | SLC6A4 (0.46) | ACHEGBA1SLC6A4HTR1AHTR2A | |
| SCHEMBL8267415 | 0.72 | ACHE (0.61) | ACHEGBA1SLC6A4HTR2AHTR2B | |
| SCHEMBL1451967 | 0.70 | ACHE (0.51) | ACHEHTR1AHTR2AHTR7DRD3 | |
| SCHEMBL577446 | 0.70 | HTR1A (0.57) | ACHEHTR1AHTR2AHTR7DRD3 | |
| SCHEMBL8854199 | 0.69 | ACHE (0.50) | ACHEHTR1AHTR2AHTR7DRD3 | |
| SCHEMBL29262843 | 0.69 | ACHE (0.51) | ACHEHTR1AHTR2AHTR7DRD3 | |
| SCHEMBL9636847 | 0.68 | GBA1 (0.50) | GBA1SLC6A4HTR2AADRA2AKDM1A | |
| SCHEMBL26042460 | 0.68 | CRBN (0.57) | ACHE | |
| SCHEMBL6955357 | 0.68 | ACHE (0.47) | ACHEHTR1AHTR2AHTR7DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114949-A | Treating disorders associated with 5HT uptake | RHONE-POULENC SANTE (FR) | 1992-05-19 | — | — | US | disclosed |