Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.74 |
| ▸ | KDM1A | O60341 | 1/20 | 0.61 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7315510 | 0.90 | KDM1A (0.67) | POLBKDM1ARCOR1MAPK1LMNA | |
| SCHEMBL7624965 | 0.86 | KDM1A (0.67) | POLBKDM1ARCOR1MAPK1LMNA | |
| SCHEMBL13679756 | 0.86 | POLB (1.00) | POLBKDM1ARCOR1LMNAALDH1A1 | |
| SCHEMBL11925397 | 0.84 | KDM1A (0.64) | POLBKDM1ARCOR1MAPK1LMNA | |
| SCHEMBL7758912 | 0.84 | KDM1A (0.64) | POLBKDM1ARCOR1MAPK1LMNA | |
| SCHEMBL2790938 | 0.83 | POLB (0.64) | POLBKDM1ARCOR1HTTSMN1; SMN2 | |
| SCHEMBL7622075 | 0.81 | KDM1A (0.60) | POLBKDM1ARCOR1MAPK1LMNA | |
| SCHEMBL7687546 | 0.80 | LMNA (0.57) | POLBKDM1ARCOR1MAPK1LMNA | |
| SCHEMBL1334862 | 0.80 | POLB (0.88) | POLBKDM1ALMNAHTTSMN1; SMN2 | |
| SCHEMBL9780058 | 0.80 | KDM1A (0.62) | KDM1ARCOR1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0308337-B1 | 4-AMINOPYRIDINE DERIVATIVES AND THEIR ACID ADDITION SALTS | MITSUBISHI KASEI CORPORATION (JP) | 1992-06-17 | — | — | EP | disclosed |
| US-4880819-A | ALZHEIMER*S DISEASE, PEPTIDE DERIVATIVE | MITSUBISHI KASEI CORPORATION (JP) | 1989-11-14 | — | — | US | disclosed |
| EP-0308337-A2 | 4-Aminopyridine derivatives and their acid addition salts | MITSUBISHI KASEI CORPORATION (JP) | 1989-03-22 | — | — | EP | disclosed |