Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.67 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MGLL | Q99685 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.51 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.51 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.51 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7624965 | 0.93 | KDM1A (0.67) | KDM1ARCOR1MAPK1ALDH1A1POLB | |
| SCHEMBL11925397 | 0.90 | KDM1A (0.64) | KDM1ARCOR1MAPK1ALDH1A1POLB | |
| SCHEMBL7758912 | 0.90 | KDM1A (0.64) | KDM1ARCOR1MAPK1ALDH1A1POLB | |
| SCHEMBL9635671 | 0.90 | POLB (0.74) | KDM1ARCOR1MAPK1ALDH1A1POLB | |
| SCHEMBL7622075 | 0.87 | KDM1A (0.60) | KDM1ARCOR1MAPK1ALDH1A1POLB | |
| SCHEMBL7687546 | 0.86 | LMNA (0.57) | KDM1ARCOR1MAPK1ALDH1A1POLB | |
| SCHEMBL9780058 | 0.86 | KDM1A (0.62) | KDM1ARCOR1ALDH1A1LMNAKMT2A | |
| SCHEMBL7406969 | 0.86 | HTT (0.59) | KDM1ARCOR1MAPK1ALDH1A1POLB | |
| SCHEMBL7758133 | 0.86 | KDM1A (0.59) | KDM1ARCOR1MAPK1ALDH1A1POLB | |
| SCHEMBL9299855 | 0.85 | POLB (0.55) | KDM1ARCOR1MAPK1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070190022-A1 | Combination methods of treating cancer | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-08-16 | — | — | US | disclosed |
| US-20070060614-A1 | Methods of treating cancer with hdac inhibitors | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2007-03-15 | — | — | US | disclosed |
| US-20070010669-A1 | Novel class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof | TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE | 2007-01-11 | — | — | US | disclosed |
| US-20070010536-A1 | Novel class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2007-01-11 | — | — | US | disclosed |
| EP-1041064-A2 | N-substituted alpha aminoacid amides as calcium channel modulators | ELI LILLY AND COMPANY LIMITED (GB) | 2000-10-04 | — | — | EP | disclosed |
| EP-0805147-A1 | Novel N-substituted alpha aminoacid amides as calcium channel modulators | LILLY INDUSTRIES LIMITED (GB) | 1997-11-05 | — | — | EP | disclosed |
| US-5280027-A | Quinazoline containing compound | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-01-18 | — | — | US | disclosed |
| EP-0254578-B1 | ANTIBIOTIC INTERMEDIATES | ELI LILLY AND COMPANY (US) | 1993-09-08 | — | — | EP | disclosed |
| EP-0459730-A2 | Anti-tumour compounds | ZENECA LIMITED (GB) | 1991-12-04 | — | — | EP | disclosed |
| EP-0094815-B1 | OLIGOPEPTIDE PRODRUGS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-01-11 | — | — | EP | disclosed |
| US-4772694-A | Chiral 3-(1,2,5-trisubstituted imidazolidinone) azetidinone antibiotic intermediates | ELI LILLY AND COMPANY (US) | 1988-09-20 | — | — | US | disclosed |
| EP-0254578-A1 | Antibiotic intermediates | ELI LILLY AND COMPANY (US) | 1988-01-27 | — | — | EP | disclosed |
| US-4479898-A | Oligopeptide prodrugs | SMITHKLINE BECKMAN CORPORATION (US) | 1984-10-30 | — | — | US | disclosed |
| US-4454065-A | INCREASE CELL MEMBRANE PERMEABILITY | SMITHKLINE BECKMAN CORPORATION (US) | 1984-06-12 | — | — | US | disclosed |
| EP-0094815-A2 | Oligopeptide prodrugs | SMITHKLINE BECKMAN CORPORATION (US) | 1983-11-23 | — | — | EP | disclosed |
| US-4183909-A | DIAGNOSTIC TOOL FOR GASTROINTESTINAL DISORDERS | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 1980-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060614-A1 | Methods of treating cancer with hdac inhibitors | HDAC5, BCL6, HDAC9 | KDM1A 49/4885RCOR1 496/4885MAPK1 4263/4885 |
| US-20070010669-A1 | Novel class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof | ACIN1, HDAC3, HDAC1 | KDM1A 45/4885RCOR1 256/4885MAPK1 2852/4885 |
| US-20070190022-A1 | Combination methods of treating cancer | HDAC5, HDAC1, HDAC4 | KDM1A 147/4885RCOR1 284/4885MAPK1 3996/4885 |
| US-20070010536-A1 | Novel class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof | ACIN1, HDAC3, HDAC1 | KDM1A 45/4885RCOR1 256/4885MAPK1 2852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.