Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.44 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9636185 | 1.00 | LMNA (0.47) | LMNANPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL9637327 | 0.99 | LMNA (0.48) | LMNANPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL9636354 | 0.96 | MEN1 (0.46) | LMNANPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL194683 | 0.92 | LMNA (0.47) | LMNANPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL9637607 | 0.84 | PKM (0.44) | LMNASMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL9636106 | 0.84 | PKM (0.44) | LMNASMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL9636348 | 0.83 | HTT (0.53) | LMNANPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL9636356 | 0.83 | PKM (0.45) | LMNANPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL10033424 | 0.76 | ALDH1A1 (0.54) | LMNANPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL11257514 | 0.75 | MEN1 (0.57) | LMNANPC1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0303232-B1 | USE OF BENZYLPYRIDINE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF DEMENTIA | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-07-29 | — | — | EP | claimed |
| EP-0303232-A2 | Use of benzylpyridine derivatives in the manufacture of a medicament for the treatment of dementia | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-02-15 | — | — | EP | claimed |
| EP-0303232-B1 | USE OF BENZYLPYRIDINE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF DEMENTIA | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-07-29 | — | — | EP | disclosed |
| US-4851414-A | AMIDO NITRO BENZYLPYRIDINES | KYOWA HAKKO KAGYO CO., LTD. (JP) | 1989-07-25 | — | — | US | disclosed |
| EP-0303232-A2 | Use of benzylpyridine derivatives in the manufacture of a medicament for the treatment of dementia | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-02-15 | — | — | EP | disclosed |