Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | GPR39 | O43194 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL194683 | 0.87 | LMNA (0.47) | HTTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL9636354 | 0.85 | MEN1 (0.46) | MEN1KMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9637327 | 0.84 | LMNA (0.48) | MEN1KMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9636320 | 0.83 | LMNA (0.47) | MEN1KMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9636356 | 0.79 | PKM (0.45) | HTTRAB9ANPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL359006 | 0.78 | HTT (0.64) | HTTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL11425242 | 0.78 | ALDH1A1 (0.56) | SMN1; SMN2MAPTMAPK1LMNAALDH1A1 | |
| SCHEMBL9637607 | 0.78 | PKM (0.44) | HTTSMN1; SMN2L3MBTL1MAPTMAPK1 | |
| SCHEMBL9636106 | 0.78 | PKM (0.44) | HTTSMN1; SMN2L3MBTL1MAPTMAPK1 | |
| SCHEMBL5159572 | 0.77 | CYP1A2 (0.52) | HTTMEN1KMT2ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0303232-B1 | USE OF BENZYLPYRIDINE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF DEMENTIA | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-07-29 | — | — | EP | claimed |
| EP-0303232-A2 | Use of benzylpyridine derivatives in the manufacture of a medicament for the treatment of dementia | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-02-15 | — | — | EP | claimed |
| JP-1042431-A | — | — | None | — | — | JP | disclosed |
| EP-0303232-B1 | USE OF BENZYLPYRIDINE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF DEMENTIA | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-07-29 | — | — | EP | disclosed |
| US-4851414-A | AMIDO NITRO BENZYLPYRIDINES | KYOWA HAKKO KAGYO CO., LTD. (JP) | 1989-07-25 | — | — | US | disclosed |
| EP-0303232-A2 | Use of benzylpyridine derivatives in the manufacture of a medicament for the treatment of dementia | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-02-15 | — | — | EP | disclosed |
| JP-S6442431-A | ANTIDEMENT AGENT | KYOWA HAKKO KOGYO KK | 1989-02-14 | — | — | JP | disclosed |