Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.55 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30852499 | 0.90 | CDC7 (0.44) | L3MBTL1TSHRRAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL9637450 | 0.82 | HPGD (0.46) | TSHRRAB9ASMN1; SMN2MAPK1KMT2A | |
| SCHEMBL20154222 | 0.75 | RAB9A (0.55) | L3MBTL1TSHRRAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL9638379 | 0.73 | HPGD (0.33) | RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL20154221 | 0.73 | RAB9A (0.56) | L3MBTL1TSHRRAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL23596009 | 0.72 | RAB9A (0.49) | L3MBTL1TSHRRAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL17870976 | 0.72 | KMT2A (0.49) | L3MBTL1RAB9ASMN1; SMN2MAPK1KMT2A | |
| SCHEMBL30852468 | 0.71 | GABRG2 (0.43) | L3MBTL1TSHRRAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL11001071 | 0.71 | ALDH1A1 (0.57) | RAB9ASMN1; SMN2MAPK1KMT2ANPC1 | |
| SCHEMBL23152503 | 0.71 | KMT2A (0.62) | L3MBTL1TSHRRAB9ASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5171860-A | Diamino isothiazole-1-oxides and 1,1 dioxides as gastric secretion inhibitors | MERCK & CO., INC. (US) | 1992-12-15 | — | — | US | disclosed |
| EP-0067436-B1 | DIAMINO ISOTHIAZOLE -1-OXIDES AND -1,1-DIOXIDES AS GASTRIC SECRETION INHIBITORS | MERCK & CO. INC. (US) | 1986-07-23 | — | — | EP | disclosed |
| EP-0067436-A2 | Diamino isothiazole -1-oxides and -1,1-dioxides as gastric secretion inhibitors | MERCK & CO. INC. (US) | 1982-12-22 | — | — | EP | disclosed |