Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9641290 | 0.74 | LMNA (0.52) | RAB9AGAAPOLBMAPTKDM4E | |
| SCHEMBL11968766 | 0.72 | GAA (1.00) | RAB9AGAATP53NPC1ALDH1A1 | |
| SCHEMBL9641234 | 0.72 | HDAC3 (0.42) | GAATP53POLBALDH1A1KDM4E | |
| SCHEMBL9640387 | 0.72 | HDAC3 (0.51) | RAB9ANPC1POLBALDH1A1MEN1 | |
| SCHEMBL27193044 | 0.69 | RAB9A (0.77) | RAB9AGAATP53NPC1POLB | |
| SCHEMBL9640366 | 0.68 | LMNA (0.43) | RAB9AMAPTMEN1KMT2AHTT | |
| SCHEMBL9641583 | 0.68 | LMNA (0.43) | RAB9AGAAPOLBALDH1A1MAPT | |
| SCHEMBL9640990 | 0.68 | RAB9A (0.53) | RAB9AGAATP53NPC1POLB | |
| SCHEMBL27264917 | 0.67 | RAB9A (1.00) | RAB9AGAANPC1POLBALDH1A1 | |
| SCHEMBL27267057 | 0.67 | RAB9A (1.00) | RAB9AGAANPC1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293880-B1 | ANTIHYPERLIPIDEMIC AND ANTIATHEROSCLEROTIC UREA COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1992-08-26 | — | — | EP | claimed |
| EP-0293880-B1 | ANTIHYPERLIPIDEMIC AND ANTIATHEROSCLEROTIC UREA COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1992-08-26 | — | — | EP | disclosed |
| US-5015644-A | Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds | WARNER-LAMBERT COMPANY (US) | 1991-05-14 | — | — | US | disclosed |
| EP-0293880-A1 | Antihyperlipidemic and antiatherosclerotic urea compounds | WARNER-LAMBERT COMPANY (US) | 1988-12-07 | — | — | EP | disclosed |