Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.39 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9641290 | 0.90 | LMNA (0.52) | LMNAMAPTALOX15HTTRAB9A | |
| SCHEMBL9641583 | 0.83 | LMNA (0.43) | LMNAMAPTALOX15HTTRAB9A | |
| SCHEMBL9641234 | 0.79 | HDAC3 (0.42) | LMNASLC6A4HDAC3HDAC1HDAC2 | |
| SCHEMBL9640387 | 0.70 | HDAC3 (0.51) | LMNARAB9ASLC6A4HDAC3HDAC1 | |
| SCHEMBL9640371 | 0.70 | SOAT1 (0.67) | LMNAMAPTSOAT2ACAT1SOAT1 | |
| SCHEMBL9194196 | 0.69 | EPHX1 (0.47) | LMNAHTTEPHX1PKM | |
| SCHEMBL9269484 | 0.69 | SMN1; SMN2 (0.43) | LMNAMAPTALOX15HTTRAB9A | |
| SCHEMBL9640319 | 0.68 | SOAT1 (0.68) | LMNAMAPTMAPK1SOAT2ACAT1 | |
| SCHEMBL9640296 | 0.68 | RAB9A (0.56) | LMNAMAPTHTTRAB9AMEN1 | |
| SCHEMBL21916840 | 0.68 | SLC6A4 (0.58) | LMNAHTTSLC6A4HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293880-B1 | ANTIHYPERLIPIDEMIC AND ANTIATHEROSCLEROTIC UREA COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1992-08-26 | — | — | EP | claimed |
| EP-0293880-B1 | ANTIHYPERLIPIDEMIC AND ANTIATHEROSCLEROTIC UREA COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1992-08-26 | — | — | EP | disclosed |
| US-5015644-A | Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds | WARNER-LAMBERT COMPANY (US) | 1991-05-14 | — | — | US | disclosed |