Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3984004 | 0.98 | LMNA (0.69) | LMNASMN1; SMN2L3MBTL1NPSR1MEN1 | |
| SCHEMBL9640359 | 0.92 | LMNA (0.59) | LMNASMN1; SMN2L3MBTL1NPSR1MEN1 | |
| SCHEMBL20960413 | 0.84 | ALDH1A1 (0.64) | LMNASMN1; SMN2L3MBTL1NPSR1ALDH1A1 | |
| SCHEMBL3373766 | 0.84 | LMNA (0.68) | LMNASMN1; SMN2L3MBTL1NPSR1MEN1 | |
| SCHEMBL9818668 | 0.81 | CNR1 (0.70) | LMNASMN1; SMN2L3MBTL1NPSR1MEN1 | |
| SCHEMBL10083664 | 0.81 | LMNA (1.00) | LMNASMN1; SMN2L3MBTL1NPSR1MEN1 | |
| SCHEMBL300331 | 0.79 | CNR1 (0.72) | LMNASMN1; SMN2L3MBTL1NPSR1MEN1 | |
| SCHEMBL7700836 | 0.79 | LMNA (0.66) | LMNASMN1; SMN2L3MBTL1NPSR1MEN1 | |
| SCHEMBL28093470 | 0.79 | SOAT2 (0.60) | LMNASMN1; SMN2L3MBTL1NPSR1MEN1 | |
| SCHEMBL17761202 | 0.78 | DPP4 (0.56) | LMNASMN1; SMN2L3MBTL1NPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293880-B1 | ANTIHYPERLIPIDEMIC AND ANTIATHEROSCLEROTIC UREA COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1992-08-26 | — | — | EP | claimed |
| EP-0293880-A1 | Antihyperlipidemic and antiatherosclerotic urea compounds | WARNER-LAMBERT COMPANY (US) | 1988-12-07 | — | — | EP | claimed |
| EP-0293880-B1 | ANTIHYPERLIPIDEMIC AND ANTIATHEROSCLEROTIC UREA COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1992-08-26 | — | — | EP | disclosed |
| EP-0293880-A1 | Antihyperlipidemic and antiatherosclerotic urea compounds | WARNER-LAMBERT COMPANY (US) | 1988-12-07 | — | — | EP | disclosed |