Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 14/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 13/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 12/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 12/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 12/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | SCN1A | P35498 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9642016 | 0.98 | CHRM3 (0.43) | CHRM3CHRM4CHRM5CHRM2CHRM1 | |
| SCHEMBL9641613 | 0.92 | BCL2 (0.47) | CHRM3CHRM4CHRM5CHRM2CHRM1 | |
| SCHEMBL9640780 | 0.84 | BCL2 (0.42) | LMNASMN1; SMN2MAPK1MEN1KMT2A | |
| SCHEMBL9092179 | 0.83 | OPRM1 (0.39) | OPRM1LMNASMN1; SMN2 | |
| SCHEMBL9640768 | 0.83 | CCR2 (0.35) | CYP2D6KCNH2LMNAMEN1KMT2A | |
| SCHEMBL9641967 | 0.79 | CHRM3 (0.34) | CHRM3 | |
| SCHEMBL9281271 | 0.76 | MAPT (0.38) | OPRM1LMNA | |
| SCHEMBL7987163 | 0.75 | CHRM2 (0.33) | CHRM3CHRM2CHRM1 | |
| SCHEMBL4378229 | 0.74 | HRH4 (0.31) | — | |
| SCHEMBL2802749 | 0.73 | KIF11 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0311447-B1 | AROMATASE INHIBITING 4(5)-IMIDAZOLES | ORION-YHTYMÀ OY (FI) | 1992-08-26 | — | — | EP | claimed |
| EP-0311447-A1 | Aromatase inhibiting 4(5)-imidazoles | ORION-YHTYMÀ OY (FI) | 1989-04-12 | — | — | EP | claimed |
| EP-0311447-B1 | AROMATASE INHIBITING 4(5)-IMIDAZOLES | ORION-YHTYMÀ OY (FI) | 1992-08-26 | — | — | EP | disclosed |
| US-5098923-A | Antiestrogens, anticarcinogenic agents or fungicides | FARMOS-YHTYMA OY (FI) | 1992-03-24 | — | — | US | disclosed |
| EP-0311447-A1 | Aromatase inhibiting 4(5)-imidazoles | ORION-YHTYMÀ OY (FI) | 1989-04-12 | — | — | EP | disclosed |