Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28608277 | 0.90 | CFTR (0.51) | CFTRPLA2G2ADHODHCDK2KDM4E | |
| SCHEMBL28496945 | 0.86 | KDM4E (0.49) | DHODHCDK2KDM4EALDH1A1SORT1 | |
| SCHEMBL30120650 | 0.86 | KDM4E (0.49) | DHODHCDK2KDM4EALDH1A1SORT1 | |
| SCHEMBL28131200 | 0.81 | L3MBTL1 (0.50) | L3MBTL1PLA2G2ANQO2KDM4EMAPT | |
| SCHEMBL19579754 | 0.80 | CFTR (0.49) | CFTRL3MBTL1DHODHCDK2KDM4E | |
| SCHEMBL28840836 | 0.80 | L3MBTL1 (0.71) | L3MBTL1PLA2G2ADHODHNQO2KDM4E | |
| SCHEMBL28131095 | 0.80 | PLA2G2A (0.62) | L3MBTL1PLA2G2ADHODHNQO2KDM4E | |
| SCHEMBL28130383 | 0.80 | PLA2G2A (0.67) | L3MBTL1PLA2G2ANQO2KDM4EALOX15 | |
| SCHEMBL22492480 | 0.78 | CFTR (0.54) | CFTRCDK2KDM4ESORT1 | |
| SCHEMBL5396165 | 0.77 | KDM4E (0.68) | L3MBTL1PLA2G2ADHODHKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106380446-B | Synthesis method of quinoline-2 formate derivative | 南阳师范学院 | 2021-06-18 | — | — | CN | disclosed |
| US-5112821-A | Excitatory amino acid antagonists which are certain thienopyridives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-5026700-A | Certain quinolines and thienopyridines as excitatory amino acid antagonists | MERRELL DOW PHARMACEUTICALS (US) | 1991-06-25 | — | — | US | disclosed |
| EP-0398283-A1 | Excitatory amino acid antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-11-22 | — | — | EP | disclosed |