Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.41 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9643429 | 1.00 | ABCB11 (0.44) | ABCB11ALOX15TOP2AEPHX2L3MBTL1 | |
| SCHEMBL9643143 | 0.92 | ABCB11 (0.43) | ABCB11ALOX15EPHX2L3MBTL1ALDH1A1 | |
| SCHEMBL9642923 | 0.92 | ABCB11 (0.43) | ABCB11ALOX15EPHX2L3MBTL1ALDH1A1 | |
| SCHEMBL9449155 | 0.90 | ABCB11 (0.52) | ABCB11ALOX15ALDH1A1GLAMAPK1 | |
| SCHEMBL9643614 | 0.84 | ABCB11 (0.45) | ABCB11ALOX15EPHX2L3MBTL1ALDH1A1 | |
| SCHEMBL9642038 | 0.84 | ABCB11 (0.45) | ABCB11ALOX15EPHX2L3MBTL1ALDH1A1 | |
| SCHEMBL9641843 | 0.84 | ABCB11 (0.41) | ABCB11ALOX15EPHX2ALDH1A1TDP1 | |
| SCHEMBL9644053 | 0.84 | ABCB11 (0.41) | ABCB11ALOX15EPHX2ALDH1A1TDP1 | |
| SCHEMBL9642233 | 0.84 | ABCB11 (0.60) | ABCB11ALOX15TOP2AEPHX2PSEN1 | |
| SCHEMBL9642996 | 0.83 | L3MBTL1 (0.44) | ALOX15TOP2AL3MBTL1ALDH1A1PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0215622-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS AND PROCESS FOR MAKING THEM | SYNTEX (U.S.A.) INC. (US) | 1992-06-17 | — | — | EP | disclosed |
| US-4946845-A | STABLE ANTIINFLAMMATORY AGENTS, LIPOXYGENASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1990-08-07 | — | — | US | disclosed |
| US-4792556-A | LIPOXYGENASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1988-12-20 | — | — | US | disclosed |
| EP-0215622-A2 | Naphthalene anti-psoriatic agents and process for making them | SYNTEX (U.S.A.) INC. (US) | 1987-03-25 | — | — | EP | disclosed |