Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.75 |
| ▸ | MAPT | P10636 | 1/20 | 0.75 |
| ▸ | PDE4A | P27815 | 1/20 | 0.75 |
| ▸ | KDR | P35968 | 1/20 | 0.75 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL11729197 | 1.00 | HIF1A (0.75) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL2136219 | 1.00 | — | — | |
| Piperazine SCHEMBL5946680 | 0.94 | HIF1A (0.67) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL27797829 | 0.94 | — | — | |
| Aziridine SCHEMBL27781146 | 0.94 | — | — | |
| SCHEMBL576335 | 0.87 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL734764 | 0.87 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL22003 | 0.87 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL3999265 | 0.87 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL577429 | 0.87 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 129 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250320423-A1 | METHOD FOR PREVENTING OR REDUCING LOW SPEED PRE-IGNITION IN DIRECT INJECTED SPARK-IGNITED ENGINES WITH MOLYBDENUM-CONTAINING LUBRICANT COMPOSITIONS | CHEVRON ORONITE CO (US) | 2025-10-16 | — | — | US | disclosed |
| EP-4608942-A2 | METHOD FOR PREVENTING OR REDUCING LOW SPEED PRE-IGNITION IN DIRECT INJECTED SPARK-IGNITED ENGINES WITH MOLYBDENUM-CONTAINING LUBRICANT COMPOSITIONS | Chevron Oronite Company LLC (US) | 2025-09-03 | — | — | EP | disclosed |
| EP-4134414-B1 | LUBRICATING OIL COMPOSITIONS CONTAINING ZIRCONIUM AND METHOD FOR PREVENTING OR REDUCING LOW SPEED PRE-IGNITION IN DIRECT INJECTED SPARK-IGNITED ENGINES | CHEVRON USA INC (US) | 2025-08-06 | — | — | EP | disclosed |
| EP-3652282-B1 | LUBRICATING OIL COMPOSITIONS CONTAINING NON-SULFUR-PHOSPHORUS CONTAINING ZINC COMPOUNDS AND METHOD FOR PREVENTING OR REDUCING LOW SPEED PRE-IGNITION IN DIRECT INJECTED SPARK-IGNITED ENGINES | CHEVRON ORONITE CO (US) | 2025-08-06 | — | — | EP | disclosed |
| US-20250188381-A1 | LUBRICATING OIL COMPOSITIONS WITH IMPROVED OXIDATIVE PERFORMANCE COMPRISING ALKYLATED DIPHENYLAMINE ANTIOXIDANT AND CARBOXYLATE DETERGENTS | CHEVRON ORONITE COMPANY LLC (US) | 2025-06-12 | — | — | US | disclosed |
| EP-3802752-B1 | METHOD FOR PREVENTING OR REDUCING LOW SPEED PRE-IGNITION IN DIRECT INJECTED SPARK-IGNITED ENGINES WITH MANGANESE-CONTAINING LUBRICANT | CHEVRON USA INC (US) | 2023-07-19 | — | — | EP | disclosed |
| US-20230085359-A1 | LUBRICATING OIL COMPOSITIONS WITH IMPROVED OXIDATIVE PERFORMANCE COMPRISING ALKYLATED DIPHENYLAMINE ANTIOXIDANT AND SULFONATE DETERGENTS | CHEVRON ORONITE COMPANY LLC (US) | 2023-03-16 | — | — | US | disclosed |
| EP-4134414-A1 | LUBRICATING OIL COMPOSITIONS CONTAINING ZIRCONIUM AND METHOD FOR PREVENTING OR REDUCING LOW SPEED PRE-IGNITION IN DIRECT INJECTED SPARK-IGNITED ENGINES | Chevron U.S.A. Inc. (US) | 2023-02-15 | — | — | EP | disclosed |
| EP-4118171-A1 | LUBRICATING OIL COMPOSITIONS WITH IMPROVED OXIDATIVE PERFORMANCE COMPRISING ALKYLATED DIPHENYLAMINE ANTIOXIDANT AND SULFONATE DETERGENTS | Chevron Oronite Company LLC (US) | 2023-01-18 | — | — | EP | disclosed |
| EP-4118170-A1 | LUBRICATING OIL COMPOSITIONS WITH IMPROVED OXIDATIVE PERFORMANCE COMPRISING ALKYLATED DIPHENYLAMINE ANTIOXIDANT AND CARBOXYLATE DETERGENTS | Chevron Oronite Company LLC (US) | 2023-01-18 | — | — | EP | disclosed |
| US-4369119-A | Antioxidant combinations of molybdenum complexes and organic sulfur compounds for lubricating oils | CHEVRON RESEARCH COMPANY (US) | 1983-01-18 | — | — | US | disclosed |
| US-4285822-A | OXIDATION RESISTANCE; OIL-SOLUBLE COMPLEX OF AN ACIDIC MOLYBDENUM COMPOUND, A BASIC NITROGEN-CONTAINING COMPOUND, AND CARBON DISULFIDE | CHEVRON RESEARCH COMPANY (US) | 1981-08-25 | — | — | US | disclosed |
| US-4283295-A | BY REACTING AMMONIUM TETRATHIAMOLYBDATE AND A BASIC NITROGEN COMPOUND | CHEVRON RESEARCH COMPANY (US) | 1981-08-11 | — | — | US | disclosed |
| US-4272387-A | Process of preparing molybdenum complexes, the complexes so-produced and lubricants containing same | CHEVRON RESEARCH COMPANY (US) | 1981-06-09 | — | — | US | disclosed |
| US-4265773-A | Process of preparing molybdenum complexes, the complexes so-produced and lubricants containing same | CHEVRON RESEARCH COMPANY (US) | 1981-05-05 | — | — | US | disclosed |
| US-4263152-A | OIL ADDITIVES COMPRISING A COMPLEX OF AN ACIDIC MOLYBDENUM COMPOUND, A BASIC NITROGEN-CONTAINING COMPOUND, AND A SULFUR SOURCE; OXIDATION RESISTANCE | CHEVRON RESEARCH COMPANY (US) | 1981-04-21 | — | — | US | disclosed |
| US-4261843-A | Reaction product of acidic molybdenum compound with basic nitrogen compound and lubricants containing same | CHEVRON RESEARCH COMPANY (US) | 1981-04-14 | — | — | US | disclosed |
| US-4259194-A | Reaction product of ammonium tetrathiomolybdate with basic nitrogen compounds and lubricants containing same | CHEVRON RESEARCH COMPANY (US) | 1981-03-31 | — | — | US | disclosed |
| US-4259195-A | ANTIOXIDANT OIL ADDITIVES | CHEVRON RESEARCH COMPANY (US) | 1981-03-31 | — | — | US | disclosed |
| US-3951614-A | REACTION PRODUCT OF A HYDROCARBYL AMINE AND POLYFUNCTIONAL COUPLING AGENT | CHEVRON RESEARCH COMPANY (US) | 1976-04-20 | — | — | US | disclosed |