Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9645434 | 0.82 | ALOX5 (0.40) | ALOX5MGLLGAAMAPTHTT | |
| SCHEMBL9644573 | 0.82 | ALOX5 (0.47) | ALOX5MGLLMAPTTP53ADRB1 | |
| SCHEMBL9645381 | 0.82 | ALDH1A1 (0.49) | ALOX5MGLLGAAMAPTMEN1 | |
| SCHEMBL10439140 | 0.70 | HTR3E (0.44) | ALOX5MGLLMAPTHTTHTR3E | |
| SCHEMBL9644634 | 0.69 | MAPT (0.46) | ALOX5MGLLGAAMAPTHTT | |
| SCHEMBL8556301 | 0.66 | ALOX5 (0.46) | ALOX5MGLLGAAMAPTHTT | |
| SCHEMBL16296350 | 0.66 | ALOX5 (0.47) | ALOX5MGLLGAAMAPTHTT | |
| SCHEMBL10361338 | 0.66 | CFTR (0.42) | ALOX5MGLLGAAMAPTHTT | |
| SCHEMBL9645791 | 0.64 | ALOX5 (0.42) | ALOX5MGLLMAPTADRB1HPGD | |
| SCHEMBL9623886 | 0.64 | ALDH1A1 (0.71) | ALOX5MGLLGAAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4970210-A | ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1990-11-13 | — | — | US | claimed |
| EP-0299449-A2 | Pyridazinone, triazinone and oxapyridazinone lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-01-18 | — | — | EP | claimed |
| JP-1156966-A | — | — | None | — | — | JP | disclosed |
| US-5086052-A | Antiarthritic, antiallergens, antiinflammatory agents; also for asthma and psoriasis | ABBOTT LABORATORIES (US) | 1992-02-04 | — | — | US | disclosed |
| US-4970210-A | ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1990-11-13 | — | — | US | disclosed |
| JP-H01156966-A | PYRIDADINONE, TRIAZINONE AND OXAPYRIDADINONE COMPOUND HAVING LIPOXYGENASE INHIBITING EFFECT | ABBOTT LAB | 1989-06-20 | — | — | JP | disclosed |
| EP-0299449-A2 | Pyridazinone, triazinone and oxapyridazinone lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-01-18 | — | — | EP | disclosed |