Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | LIG1 | P18858 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.33 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.31 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10402113 | 0.99 | MPO (0.37) | MPOGAAKDM4ESMN1; SMN2HIF1A | |
| Hydrochloric Acid SCHEMBL10401658 | 0.97 | MPO (0.36) | MPOGAAKDM4ESMN1; SMN2HIF1A | |
| SCHEMBL9647526 | 0.89 | PLK1 (0.38) | GAAKDM4ESMN1; SMN2HMGB1LMNA | |
| SCHEMBL9647479 | 0.89 | P2RX7 (0.39) | GAAKDM4EHMGB1ALOX5 | |
| Hydrochloric Acid SCHEMBL10402047 | 0.88 | PLK1 (0.37) | GAAKDM4ESMN1; SMN2HMGB1LMNA | |
| SCHEMBL9518487 | 0.86 | HMGB1 (0.48) | GAAKDM4ESMN1; SMN2HMGB1LMNA | |
| SCHEMBL8088780 | 0.85 | — | — | |
| Mivazerol SCHEMBL8097939 | 0.85 | PARP1 (0.39) | KDM4EHMGB1 | |
| Mivazerol SCHEMBL593708 | 0.85 | PARP1 (0.39) | KDM4EHMGB1 | |
| Hydrochloric Acid SCHEMBL10401999 | 0.85 | HMGB1 (0.47) | GAAKDM4ESMN1; SMN2HMGB1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0341231-B1 | SUBSTITUTED 1-(1H-IMIDAZOL-4-YL)ALKYL BENZAMIDES | U C B, S.A. (BE) | 1992-11-19 | — | — | EP | disclosed |
| EP-0341231-A1 | Substituted 1-(1H-imidazol-4-yl)alkyl benzamides | U C B, S.A. (BE) | 1989-11-08 | — | — | EP | disclosed |