Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | G6PD | P11413 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9644526 | 0.82 | KMT2A (0.39) | ALOX5CFTRALDH1A1SMN1; SMN2GAA | |
| SCHEMBL9645196 | 0.78 | LMNA (0.37) | ELANEALOX5CFTRKDM4EALDH1A1 | |
| SCHEMBL9644474 | 0.71 | GSK3A (0.41) | ALOX5CFTRKDM4EALDH1A1LMNA | |
| SCHEMBL9646990 | 0.67 | ELANE (0.37) | ELANEALOX5CFTRLMNASMN1; SMN2 | |
| SCHEMBL9645370 | 0.66 | DDB1 (0.42) | ELANECFTRKDM4EALDH1A1LMNA | |
| SCHEMBL9645716 | 0.65 | ALOX5 (0.46) | ELANEALOX5ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL9644496 | 0.60 | KMT2A (0.41) | KDM4EALDH1A1HTTSMN1; SMN2GAA | |
| SCHEMBL9891789 | 0.60 | MAPK1 (0.62) | ALDH1A1LMNAHTTSMN1; SMN2GAA | |
| SCHEMBL9644558 | 0.60 | ALOX5 (0.38) | ALOX5SMN1; SMN2GAAG6PDL3MBTL1 | |
| SCHEMBL1230085 | 0.60 | CFTR (0.59) | CFTRKDM4ESMN1; SMN2GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5086052-A | Antiarthritic, antiallergens, antiinflammatory agents; also for asthma and psoriasis | ABBOTT LABORATORIES (US) | 1992-02-04 | — | — | US | disclosed |
| US-4970210-A | ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1990-11-13 | — | — | US | disclosed |