Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | CTSG | P08311 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | CTRC | Q99895 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | RGS4 | P49798 | 1/20 | 0.38 |
| ▸ | RGS8 | P57771 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9646990 | 0.81 | ELANE (0.37) | CFTRELANEGAAGSK3AGSK3B | |
| SCHEMBL9644474 | 0.71 | GSK3A (0.41) | CFTRGAAGSK3AGSK3BMGLL | |
| SCHEMBL1078286 | 0.68 | SIGMAR1 (0.48) | ELANEF2PLGCTSGCMA1 | |
| SCHEMBL9645360 | 0.68 | DDB1 (0.53) | DDB1CRBNGAAMEN1KMT2A | |
| SCHEMBL4619566 | 0.67 | GSK3A (0.46) | DDB1CRBNELANEF2PLG | |
| SCHEMBL9645722 | 0.66 | ELANE (0.35) | CFTRELANEGAAGSK3AGSK3B | |
| SCHEMBL9645196 | 0.66 | LMNA (0.37) | CFTRELANEGAAMEN1KMT2A | |
| SCHEMBL9645637 | 0.66 | CES2 (0.41) | DDB1CRBNCFTRGAAKMT2A | |
| SCHEMBL9644526 | 0.66 | KMT2A (0.39) | CFTRGAAGSK3AGSK3BMEN1 | |
| SCHEMBL7747499 | 0.63 | DDB1 (0.47) | DDB1CRBNELANEF2PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5086052-A | Antiarthritic, antiallergens, antiinflammatory agents; also for asthma and psoriasis | ABBOTT LABORATORIES (US) | 1992-02-04 | — | — | US | disclosed |
| US-4970210-A | ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1990-11-13 | — | — | US | disclosed |
| EP-0299449-A2 | Pyridazinone, triazinone and oxapyridazinone lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-01-18 | — | — | EP | disclosed |