Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Pramiracetam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D known ✓ | P25100 | 4/20 | 0.41 |
| ▸ | ADRA1A known ✓ | P35348 | 4/20 | 0.41 |
| ▸ | ADRA1B known ✓ | P35368 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | SLC8A1 | P32418 | 1/20 | 0.38 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pramiracetam SCHEMBL120423 | 0.82 | LMNA (0.46) | LMNANQO2HTTTSHRADRA1D | |
| Pramiracetam SCHEMBL1171471 | 0.79 | LMNA (0.46) | LMNANQO2HTTTSHRADRA1D | |
| Pramiracetam SCHEMBL195465 | 0.79 | LMNA (0.48) | LMNANQO2HTTTSHRADRA1D | |
| Pramiracetam SCHEMBL11556360 | 0.78 | LMNA (0.47) | LMNANQO2HTTTSHRADRA1D | |
| Pramiracetam SCHEMBL121209 | 0.78 | LMNA (0.47) | LMNANQO2HTTTSHRADRA1D | |
| Pramiracetam SCHEMBL4431064 | 0.70 | LMNA (0.40) | LMNANQO2HTTTSHRADRA1D | |
| Pramiracetam SCHEMBL2136275 | 0.68 | LMNA (0.57) | LMNANQO2HTTTSHRADRA1D | |
| SCHEMBL9387464 | 0.67 | TDP1 (0.55) | LMNAHTTALDH1A1TDP1 | |
| Sulfuric Acid SCHEMBL11641651 | 0.67 | TDP1 (0.58) | LMNAHTTALDH1A1TDP1 | |
| Sulfuric Acid SCHEMBL9644820 | 0.67 | TDP1 (0.58) | LMNAHTTALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0345787-B1 | DRUG IN COMBINATION WITH FLAVOR MASKING AGENT AND METHOD FOR MAKING SAME | WARNER-LAMBERT COMPANY (US) | 1992-11-11 | — | — | EP | disclosed |
| US-4910023-A | Containing silica | WARNER-LAMBERT COMPANY (US) | 1990-03-20 | — | — | US | disclosed |
| EP-0345787-A2 | Drug in combination with flavor masking agent and method for making same | WARNER-LAMBERT COMPANY (US) | 1989-12-13 | — | — | EP | disclosed |