Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10659715 | 0.95 | ENPP2 (0.43) | CSNK1EMAPK1TP53CYP1A2CYP3A4 | |
| SCHEMBL1945278 | 0.90 | ENPP2 (0.44) | CYP3A4NFKB1ALDH1A1SMN1; SMN2ENPP2 | |
| SCHEMBL3189343 | 0.86 | LPL (0.44) | CSNK1EMAPK1TP53CYP1A2CYP3A4 | |
| SCHEMBL10359982 | 0.85 | MAPK1 (0.44) | CSNK1EMAPK1TP53CYP1A2CYP3A4 | |
| SCHEMBL9835921 | 0.84 | LPL (0.54) | LTB4R | |
| SCHEMBL10638974 | 0.84 | MAPK1 (0.43) | CSNK1EMAPK1TP53CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL10360268 | 0.83 | MAPK1 (0.55) | MAPK1TP53CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL27536091 | 0.83 | LMNA (0.53) | CYP3A4TSHRNFKB1HIF1AALDH1A1 | |
| SCHEMBL19711102 | 0.83 | HTR2A (0.41) | CSNK1EENPP2 | |
| SCHEMBL610307 | 0.82 | LPL (0.49) | LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5173496-A | Antiinflammatory agents | ICI PHARMA (FR) | 1992-12-22 | — | — | US | disclosed |
| EP-0284174-B1 | THERAPEUTIC PREPARATIONS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-29 | — | — | EP | disclosed |
| EP-0284174-A1 | Therapeutic preparations | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-09-28 | — | — | EP | disclosed |